Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | LOX | P28300 | 1/20 | 0.31 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652919 | 0.86 | CNR2 (0.36) | CNR2CYP3A4POLBRAB9APTGDR2 | |
| SCHEMBL2653840 | 0.83 | STAT3 (0.37) | CYP3A4POLBPTGDR2CTDSP1 | |
| SCHEMBL2652827 | 0.81 | PTGS2 (0.42) | CNR2CYP3A4 | |
| SCHEMBL2653280 | 0.80 | PTGS2 (0.44) | CNR2CYP3A4 | |
| SCHEMBL2652798 | 0.77 | ALDH1A1 (0.42) | CYP3A4POLB | |
| SCHEMBL2655064 | 0.76 | NAMPT (0.41) | — | |
| SCHEMBL2653194 | 0.72 | CYP3A4 (0.39) | CYP3A4PTGDR2 | |
| SCHEMBL2653490 | 0.71 | CYP3A4 (0.41) | CYP3A4PTGDR2 | |
| SCHEMBL2654413 | 0.71 | PTGDR2 (0.51) | CYP3A4POLBRAB9APTGDR2NPC1 | |
| SCHEMBL2653857 | 0.71 | PNMT (0.37) | CNR2POLBCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |