Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653267 | 0.86 | CA2 (0.38) | CNR2RAB9APOLBCYP3A4NPC1 | |
| SCHEMBL2653280 | 0.84 | PTGS2 (0.44) | CNR2CYP3A4ALDH1A1LMNAKMT2A | |
| SCHEMBL2652827 | 0.83 | PTGS2 (0.42) | CNR2CYP3A4ALDH1A1LMNAKMT2A | |
| SCHEMBL2653857 | 0.83 | PNMT (0.37) | CNR2POLBPNMTRORC | |
| SCHEMBL2652798 | 0.81 | ALDH1A1 (0.42) | POLBCYP3A4ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2653840 | 0.81 | STAT3 (0.37) | POLBCYP3A4ALDH1A1PTGDR2 | |
| SCHEMBL2653490 | 0.74 | CYP3A4 (0.41) | CYP3A4KMT2APTGDR2 | |
| SCHEMBL2654413 | 0.74 | PTGDR2 (0.51) | RAB9APOLBCYP3A4NPC1SMN1; SMN2 | |
| SCHEMBL2655512 | 0.73 | PTGDR2 (0.55) | RAB9ACYP3A4NPC1KMT2APTGDR2 | |
| SCHEMBL2653194 | 0.72 | CYP3A4 (0.39) | CYP3A4PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |