Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28612752 | 0.85 | RAB9A (0.43) | RAB9APKMPRMT5WDR77MAPT | |
| SCHEMBL4617692 | 0.78 | KDM4E (0.47) | RAB9APKMMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL2653153 | 0.77 | ALDH1A1 (0.54) | PKMMAPTHTTMEN1KMT2A | |
| SCHEMBL4617042 | 0.73 | KDM4E (0.48) | RAB9AMAPTKDM4EMEN1KMT2A | |
| SCHEMBL4616855 | 0.73 | RAB9A (0.67) | RAB9APKMMAPTKDM4EHTT | |
| SCHEMBL1581947 | 0.72 | RAB9A (0.52) | RAB9APKMMAPTKDM4EHTT | |
| SCHEMBL4617115 | 0.72 | RAB9A (0.45) | RAB9APKMPRMT5WDR77MAPT | |
| SCHEMBL2652827 | 0.72 | PTGS2 (0.42) | MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL2653280 | 0.71 | PTGS2 (0.44) | MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL2652919 | 0.71 | CNR2 (0.36) | RAB9AKMT2ASMN1; SMN2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |