SCHEMBL26548838

SCHEMBL26548838

C[Si](C)(C)c1ccc(-c2ccc3ccc(-c4ccc(-c5ccc(F)cc5)nc4)cc3c2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDO2 P48775 2/20 0.42
IDO1 P14902 1/20 0.42
NPC1 O15118 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
PDGFRB P09619 2/20 0.40
PDGFRA P16234 2/20 0.40
GRM5 P41594 1/20 0.38
PGR P06401 1/20 0.37
ABL1 P00519 3/20 0.36
AURKA O14965 1/20 0.36
NTRK1 P04629 1/20 0.36
LCK P06239 1/20 0.36
CSF1R P07333 1/20 0.36
RET P07949 1/20 0.36
MET P08581 1/20 0.36
PIM1 P11309 1/20 0.36
FLT3 P36888 1/20 0.36
MAPK8 P45983 1/20 0.36
CDK8 P49336 1/20 0.36
MAP2K1 Q02750 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26548851 1.00 TDO2 (0.42) TDO2IDO1NPC1RXFP1PDGFRB
SCHEMBL26548365 0.96 TDO2 (0.43) TDO2IDO1NPC1RXFP1PDGFRB
SCHEMBL26548340 0.96 TDO2 (0.43) TDO2IDO1NPC1RXFP1PDGFRB
SCHEMBL26548853 0.93 HSD17B1 (0.40) TDO2IDO1NPC1HSD17B1HSD17B2
SCHEMBL26548830 0.89 NPC1 (0.47) TDO2IDO1NPC1RXFP1PDGFRB
SCHEMBL26549312 0.89 PDGFRB (0.48) TDO2IDO1NPC1RXFP1PDGFRB
SCHEMBL26549325 0.89 PDGFRB (0.48) TDO2IDO1NPC1RXFP1PDGFRB
SCHEMBL26548367 0.88 HSD17B1 (0.41) TDO2IDO1NPC1RXFP1PDGFRB
SCHEMBL26549002 0.86 PGR (0.46) TDO2IDO1NPC1PDGFRBPDGFRA
SCHEMBL26548657 0.86 PGR (0.46) TDO2IDO1NPC1PDGFRBPDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230337527-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME LAPTO CO., LTD. (KR) 2023-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230337527-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME AOC1, ODC1, PIEZO1 TDO2 1074/4885IDO1 2053/4885NPC1 1199/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.