SCHEMBL26548853

SCHEMBL26548853

C[Si](C)(C)c1ccc(-c2ccc3ccc(-c4ccc(-c5ccc([Si](C)(C)C)cc5)nc4)cc3c2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B1 P14061 1/20 0.40
HSD17B2 P37059 1/20 0.40
ESR2 Q92731 3/20 0.35
ESR1 P03372 2/20 0.35
CASP3 P42574 2/20 0.35
SENP7 Q9BQF6 2/20 0.35
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
CYP11B2 P19099 3/20 0.35
CYP17A1 P05093 2/20 0.35
CYP11B1 P15538 2/20 0.34
CYP19A1 P11511 1/20 0.34
PRKCZ Q05513 1/20 0.33
FTO Q9C0B1 1/20 0.33
TDO2 P48775 6/20 0.33
IDO1 P14902 5/20 0.33
PIK3CD O00329 1/20 0.32
PIK3CA P42336 1/20 0.32
PIK3CB P42338 1/20 0.32
PIK3CG P48736 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26548367 0.95 HSD17B1 (0.41) HSD17B1HSD17B2ESR2ESR1CASP3
SCHEMBL26548851 0.93 TDO2 (0.42) HSD17B1HSD17B2CASP3SENP7NPC1
SCHEMBL26548838 0.93 TDO2 (0.42) HSD17B1HSD17B2CASP3SENP7NPC1
SCHEMBL26548720 0.93 GAK (0.40) CYP11B2CYP17A1CYP11B1CYP19A1PRKCZ
SCHEMBL26548691 0.91 CYP11B2 (0.44) HSD17B1HSD17B2ESR2ESR1NPC1
SCHEMBL26548845 0.90 TDO2 (0.45) CYP11B2CYP11B1TDO2IDO1
SCHEMBL26548850 0.90 TDO2 (0.45) CYP11B2CYP11B1TDO2IDO1
SCHEMBL26548178 0.89 CYP11B1 (0.45) HSD17B1HSD17B2ESR2ESR1NPC1
SCHEMBL26549326 0.88 ESR2 (0.46) HSD17B1HSD17B2ESR2PIK3CDPIK3CA
SCHEMBL26548340 0.88 TDO2 (0.43) HSD17B1HSD17B2CASP3SENP7NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230337527-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME LAPTO CO., LTD. (KR) 2023-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230337527-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME AOC1, ODC1, PIEZO1 HSD17B1 1717/4885HSD17B2 2087/4885ESR2 1164/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.