Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.31 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.31 |
| ▸ | NNMT | P40261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841990 | 0.80 | ESR1 (0.36) | ESR1ESR2PPARG | |
| SCHEMBL12924617 | 0.77 | MTNR1A (0.49) | FFAR1MTNR1A | |
| SCHEMBL29144076 | 0.76 | SIRT6 (0.46) | SIRT6NNMT | |
| SCHEMBL30242017 | 0.76 | SIRT6 (0.46) | SIRT6NNMT | |
| SCHEMBL1851646 | 0.74 | ADRA2A (0.41) | FFAR1CAPN1 | |
| SCHEMBL12896080 | 0.73 | PARP10 (0.45) | FFAR1 | |
| SCHEMBL25469623 | 0.73 | PARP10 (0.47) | FFAR1 | |
| SCHEMBL22557435 | 0.73 | FFAR1 (0.41) | FFAR1CAPN1NNMT | |
| SCHEMBL15540157 | 0.72 | IDO1 (0.36) | MTNR1ACAPN1 | |
| SCHEMBL29308626 | 0.71 | FPR2 (0.45) | FFAR1CAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960385-A1 | SUBSTITUTED DIHYDROISOINDOLONES AS ALLOSTERIC MODULATORS OF GLUCOKINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-27 | — | — | EP | claimed |
| WO-2007053503-A1 | SUBSTITUTED DIHYDROISOINDOLONES AS ALLOSTERIC MODULATORS OF GLUCOKINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-10 | — | — | WO | claimed |