Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 10/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2658638 | 0.88 | LCK (0.35) | LCKIRAK4FGFR1 | |
| SCHEMBL2657525 | 0.85 | GABRP (0.36) | LCKIRAK4FGFR1ROCK1CDK2 | |
| SCHEMBL2656663 | 0.85 | GABRA1 (0.43) | LCKIRAK4FGFR1 | |
| SCHEMBL2657177 | 0.81 | GABRA1 (0.51) | LCKFGFR1 | |
| SCHEMBL2657138 | 0.79 | GABRA1 (0.53) | IRAK4FGFR1CDK2 | |
| SCHEMBL2669851 | 0.78 | LCK (0.43) | LCKIRAK4FGFR1ROCK1 | |
| SCHEMBL2657774 | 0.76 | JAK2 (0.43) | LCKIRAK4CDK2 | |
| SCHEMBL2659103 | 0.76 | FGFR1 (0.43) | FGFR1 | |
| SCHEMBL1616006 | 0.73 | FGFR1 (0.44) | FGFR1 | |
| SCHEMBL1615750 | 0.73 | FGFR1 (0.44) | FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010055126-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2010-05-20 | — | — | WO | claimed |
| WO-2010055126-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2010-05-20 | — | — | WO | disclosed |