Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOD1 | P00441 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2349455 | 0.84 | ACHE (0.44) | SOD1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL2980656 | 0.84 | ALDH1A1 (0.51) | SOD1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL15685014 | 0.84 | KDM4E (0.45) | CA1CA2CA9L3MBTL1POLB | |
| SCHEMBL26571369 | 0.83 | NPC1 (0.43) | SOD1CYP2C9CA1CA2CA9 | |
| SCHEMBL9451441 | 0.82 | CA2 (0.66) | CA1CA2CA9HDAC4HDAC2 | |
| SCHEMBL2980637 | 0.81 | SOD1 (0.46) | SOD1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL18507891 | 0.80 | CA1 (0.60) | CA1CA2CA9ELANE | |
| SCHEMBL7766026 | 0.79 | MEN1 (0.45) | SOD1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL2978101 | 0.78 | ALDH1A1 (0.51) | CYP3A4CYP2C9CYP2C19L3MBTL1LMNA | |
| SCHEMBL22719662 | 0.78 | KIF11 (0.49) | CYP2C9CYP2C19CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230331721-A1 | POTENT AND SELECTIVE COVALENT INHIBITORS OF SERINE-ARGININE PROTEIN KINASE (SRPK) 1 AND SRPK2 AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-10-19 | — | — | US | disclosed |
| US-20230331721-A1 | POTENT AND SELECTIVE COVALENT INHIBITORS OF SERINE-ARGININE PROTEIN KINASE (SRPK) 1 AND SRPK2 AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230331721-A1 | POTENT AND SELECTIVE COVALENT INHIBITORS OF SERINE-ARGININE PROTEIN KINASE (SRPK) 1 AND SRPK2 AND USES THEREOF | SRPK1, SRPK2, SRPK3 | SOD1 2194/4885CYP3A4 4785/4885CYP2C9 4779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.