SCHEMBL2657529

SCHEMBL2657529

CC=C[CH]c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.46
ALDH1A1 P00352 4/20 0.39
TSHR P16473 2/20 0.39
CYP2A6 P11509 1/20 0.39
TRPA1 O75762 3/20 0.39
LMNA P02545 2/20 0.39
ALOX5 P09917 1/20 0.39
MAPK1 P28482 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.38
CHAT P28329 2/20 0.36
NFE2L2 Q16236 2/20 0.35
RELA Q04206 1/20 0.34
AKR1C3 P42330 1/20 0.34
GLA P06280 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
CYP19A1 P11511 1/20 0.33
MAOA P21397 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3654206 1.00 MAOB (0.46) MAOBALDH1A1TSHRCYP2A6TRPA1
SCHEMBL7519973 1.00 MAOB (0.46) MAOBALDH1A1TSHRCYP2A6TRPA1
SCHEMBL27372971 0.97 MAOB (0.43) MAOBALDH1A1TSHRCYP2A6TRPA1
SCHEMBL28054656 0.85 ALDH1A1 (0.41) ALDH1A1LMNAMAPK1L3MBTL1TDP1
SCHEMBL6330351 0.82 MAOB (0.56) MAOBALDH1A1TSHRCYP2A6TRPA1
SCHEMBL6330348 0.82 MAOB (0.56) MAOBALDH1A1TSHRCYP2A6TRPA1
SCHEMBL3949316 0.77
SCHEMBL627659 0.76 MAOB (0.74) MAOBALDH1A1TRPA1LMNAALOX5
SCHEMBL9454821 0.76 MAOB (0.74) MAOBALDH1A1TRPA1LMNAALOX5
SCHEMBL21457949 0.76 MAOB (0.74) MAOBALDH1A1TRPA1LMNAALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2786985-A2 Antagonists of the glucagon receptor Metabasis Therapeutics, Inc. (US) 2014-10-08 EP claimed
JP-4216713-B2 2009-01-28 JP claimed
EP-1404324-A4 PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF XENOPORT INC (US) 2004-12-22 EP claimed
JP-2004536873-A 2004-12-09 JP claimed
EP-1404324-A2 PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF Xenoport, Inc. (US) 2004-04-07 EP claimed
WO-2002100347-A2 PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF XENOPORT, INC. (US) 2002-12-19 WO claimed
US-12017980-B2 Monofunctional phenolic compound, active ester resin and method for producing the same, and thermosetting resin composition and cured product thereof DIC CORPORATION (JP) 2024-06-25 US disclosed
US-11993617-B2 Organic luminescent material having an ancillary ligand with a partially fluorine-substituted substituent Beijing Summer Sprout Technology Co., Ltd. (CN) 2024-05-28 US disclosed
US-20230144101-A1 LIGHT-EMITTING MATERIAL WITH A POLYCYCLIC LIGAND Beijing Summer Sprout Technology Co., Ltd. (CN) 2023-05-11 US disclosed
US-11466026-B2 Organic electroluminescent materials and devices Beijing Summer Sprout Technology Co., Ltd. (CN) 2022-10-11 US disclosed
US-20220033333-A1 MONOFUNCTIONAL PHENOLIC COMPOUND, ACTIVE ESTER RESIN AND METHOD FOR PRODUCING THE SAME, AND THERMOSETTING RESIN COMPOSITION AND CURED PRODUCT THEREOF DIC CORPORATION (JP) 2022-02-03 US disclosed
US-10807946-B2 Antagonists of the glucagon receptor METABASIS THERAPEUTICS, INC. (US) 2020-10-20 US disclosed
WO-2020059625-A1 PHENOL COMPOUND, ACTIVE ESTER RESIN, PRODUCTION METHOD FOR ACTIVE ESTER RESIN, THERMOSETTING RESIN COMPOSITION, AND CURED PRODUCT OF THERMOSETTING RESIN COMPOSITION DIC株式会社 2020-03-26 WO disclosed
WO-2000066588-A1 DIRECT C-14 OXIDATION OF OPIOIDS THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENTOF HEALTH A ND HUMAN SERVICES (US) 2000-11-09 WO disclosed
WO-2000020441-A2 CYCLIC PEPTIDES AS ANTIFUNGAL AGENTS ABBOTT LABORATORIES (US) 2000-04-13 WO disclosed
US-5017724-A Antihypoxic, CNS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1991-05-21 US disclosed
EP-0267024-B1 HYDROFLUORENE DERIVATIVES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1991-05-02 EP disclosed
EP-0321155-A2 Ethylenically-unsaturated ethers of alkenyl phenols as reactive diluents for bismaleimides AMOCO CORPORATION (US) 1989-06-21 EP disclosed
US-4812511-A FIBER REINFORCED COMPOSITES AMOCO CORPORATION (US) 1989-03-14 US disclosed
EP-0267024-A2 Hydrofluorene derivatives OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1988-05-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11993617-B2 Organic luminescent material having an ancillary ligand with a partially fluorine-substituted substituent KCNK10, KCNQ1, KCNK2 MAOB 403/4885ALDH1A1 1128/4885TSHR 2734/4885
US-11466026-B2 Organic electroluminescent materials and devices OCIAD1, OCIAD2, SLCO4C1 MAOB 699/4885ALDH1A1 1580/4885TSHR 4433/4885
US-12017980-B2 Monofunctional phenolic compound, active ester resin and method for producing the same, and thermosetting resin composition and cured product thereof JMJD7, KDM7A, KDM4A MAOB 1149/4885ALDH1A1 474/4885TSHR 4809/4885
US-20220033333-A1 MONOFUNCTIONAL PHENOLIC COMPOUND, ACTIVE ESTER RESIN AND METHOD FOR PRODUCING THE SAME, AND THERMOSETTING RESIN COMPOSITION AND CURED PRODUCT THEREOF JMJD7, KDM7A, KDM4A MAOB 1149/4885ALDH1A1 474/4885TSHR 4809/4885
US-10807946-B2 Antagonists of the glucagon receptor GLP1R, GCGR, GPR119 MAOB 3523/4885ALDH1A1 4657/4885TSHR 64/4885
US-20230144101-A1 LIGHT-EMITTING MATERIAL WITH A POLYCYCLIC LIGAND TRPC4, CRY1, TRPC1 MAOB 4062/4885ALDH1A1 2910/4885TSHR 4335/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.