Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.64 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29733457 | 1.00 | AXL (0.64) | AXLGSTP1SMN1; SMN2NOTUMGPR119 | |
| SCHEMBL2644154 | 0.81 | GSTP1 (0.51) | AXLGSTP1SMN1; SMN2NISCHPDE4B | |
| SCHEMBL6858128 | 0.81 | RAB9A (0.49) | AXLSMN1; SMN2HDAC4HDAC2HDAC8 | |
| SCHEMBL11846026 | 0.79 | AXL (0.92) | AXLSMN1; SMN2GPR119PDE3BPDE3A | |
| SCHEMBL2375581 | 0.78 | AXL (1.00) | AXLSMN1; SMN2GPR119PDE3BPDE3A | |
| SCHEMBL27995075 | 0.78 | AXL (0.77) | AXLSMN1; SMN2GPR119NISCHPDE3B | |
| SCHEMBL11094190 | 0.76 | PDE3B (0.49) | GSTP1SMN1; SMN2NOTUMNISCHPDE4B | |
| SCHEMBL20279531 | 0.72 | AXL (0.67) | AXLSMN1; SMN2PDE4BPDE3BPDE3A | |
| SCHEMBL5561070 | 0.72 | AXL (0.67) | AXLSMN1; SMN2NOTUMPDE4BPDE3B | |
| SCHEMBL13335345 | 0.72 | AXL (0.67) | AXLSMN1; SMN2PDE4BPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11970610-B2 | Tire rubber composition using pyrazalone-based compound | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2024-04-30 | — | — | US | disclosed |
| US-20230183457-A1 | TIRE RUBBER COMPOSITION USING PYRAZALONE-BASED COMPOUND | THE GOODYEAR TIRE & RUBBER COMPANY | 2023-06-15 | — | — | US | disclosed |
| US-20220106463-A1 | RUBBER COMPOSITION, RUBBER MATERIAL, USE OF SAME, AND ADDITIVE | OTSUKA CHEMICAL CO., LTD. (JP) | 2022-04-07 | — | — | US | disclosed |
| EP-3845591-A1 | RUBBER COMPOSITION, RUBBER MATERIAL, USE OF SAME AND ADDITIVE | Otsuka Chemical Co., Ltd. (JP) | 2021-07-07 | — | — | EP | disclosed |
| CN-112533991-A | Rubber composition, rubber material, use thereof, and additive | 大塚化学株式会社 | 2021-03-19 | — | — | CN | disclosed |
| US-7799818-B2 | Pyrazole derivatives, compositions containing such compounds and methods of use | MERCK SHARP & DOHME CORP. (US) | 2010-09-21 | — | — | US | disclosed |
| US-7598285-B2 | Pyrazole derivatives, compositions containing such compounds and methods of use | MERCK & CO., INC (US) | 2009-10-06 | — | — | US | disclosed |
| US-20090176854-A1 | N-[4-((1S)-1-{3-(3,5-Dichlorophenyl)-5-[6-(trifluoromethoxy)-2-naphthyl]-1H-pyrazol-1-yl}ethyl)benzoyl]- beta -alanine; type 2 diabetes, hyperglycemia, or insulin resistance | MERCK SHARP & DOHME LLC | 2009-07-09 | — | — | US | disclosed |
| US-20050272794-A1 | Pyrazole derivatives, compositions containing such compounds and methods of use | MERCK SHARP & DOHME LLC | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272794-A1 | Pyrazole derivatives, compositions containing such compounds and methods of use | PC, GOT2, PNLIP | AXL 4223/4885GSTP1 2296/4885SMN1; SMN2 2913/4885 |
| US-20090176854-A1 | N-[4-((1S)-1-{3-(3,5-Dichlorophenyl)-5-[6-(trifluoromethoxy)-2-naphthyl]-1H-pyrazol-1-yl}ethyl)benzoyl]- beta -alanine; type 2 diabetes, hyperglycemia, or insulin resistance | GOT2, GOT1, IAPP | AXL 4299/4885GSTP1 1203/4885SMN1; SMN2 1736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.