Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.30 |
| ▸ | TOP2A | P11388 | 1/20 | 0.30 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.30 |
| ▸ | TACR3 | P29371 | 1/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.30 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.30 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30622860 | 0.85 | GPR119 (0.40) | NPC1 | |
| SCHEMBL26645391 | 0.80 | MAPK14 (0.48) | MAPK14MAPK11CSNK1DCSNK1EKCNH2 | |
| SCHEMBL26645533 | 0.78 | — | — | |
| SCHEMBL26645167 | 0.78 | SRC (0.43) | GRM5TGFBR1RECQLGAAMAPK14 | |
| SCHEMBL26645595 | 0.77 | SMO (0.34) | SMOGAAGHSRNPC1TOP2A | |
| SCHEMBL26645666 | 0.77 | SMO (0.34) | SMOGAAGHSRNPC1TOP2A | |
| SCHEMBL26645383 | 0.77 | SMO (0.34) | SMOGAAGHSRNPC1TOP2A | |
| SCHEMBL26645397 | 0.75 | BCHE (0.41) | TGFBR1GHSRMAPK14MAPK11CSNK1D | |
| SCHEMBL26645543 | 0.74 | GHSR (0.48) | GHSRCSNK1E | |
| SCHEMBL26645178 | 0.73 | SMO (0.31) | SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |