Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 8/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26645578 | 0.85 | GRM5 (0.50) | CYP3A4CYP3A5GRM5MEN1KMT2A | |
| SCHEMBL26645758 | 0.82 | GRM5 (0.43) | CYP3A4CYP3A5GRM5KCNH2MEN1 | |
| SCHEMBL26645284 | 0.81 | MKNK1 (0.55) | CYP3A4CYP3A5MKNK1MEN1KMT2A | |
| SCHEMBL16711314 | 0.81 | GRM5 (0.50) | GRM5KCNH2NR1H2 | |
| SCHEMBL26645565 | 0.80 | MKNK1 (0.54) | CYP3A4CYP3A5MKNK1MEN1KMT2A | |
| SCHEMBL30623013 | 0.80 | GRM5 (0.45) | CYP3A4CYP3A5GRM5MKNK1MEN1 | |
| SCHEMBL18200209 | 0.79 | GRM5 (0.47) | CYP3A4CYP3A5GRM5POLB | |
| SCHEMBL26645129 | 0.79 | RORC (0.47) | CYP3A4CYP3A5MKNK1MEN1KMT2A | |
| SCHEMBL16711195 | 0.78 | GRM5 (0.50) | GRM5NR1H2 | |
| SCHEMBL26645545 | 0.78 | GRM5 (0.45) | GRM5MEN1KMT2ANR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4519265-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | Bayer Aktiengesellschaft (DE) | 2025-03-12 | — | — | EP | disclosed |
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |