Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26665761 | 0.87 | KDM4E (0.59) | KDM4ESMN1; SMN2HPGDHTTNPSR1 | |
| SCHEMBL26665773 | 0.86 | KDM4E (0.56) | KDM4ESMN1; SMN2HPGDHTTNPSR1 | |
| SCHEMBL26665762 | 0.86 | KDM4E (0.56) | KDM4ESMN1; SMN2HPGDHTTNPSR1 | |
| SCHEMBL26665755 | 0.86 | KDM4E (0.56) | KDM4ESMN1; SMN2HPGDHTTNPSR1 | |
| SCHEMBL26665768 | 0.86 | HTT (0.61) | KDM4ESMN1; SMN2HPGDHTTNPSR1 | |
| SCHEMBL26665775 | 0.79 | KDM4E (0.48) | KDM4ESMN1; SMN2HPGDHTTNPSR1 | |
| SCHEMBL26665754 | 0.77 | FNTA (0.48) | CA12CA1CA2CA7CA9 | |
| SCHEMBL26830000 | 0.74 | FNTA (0.54) | KDM4ESMN1; SMN2HPGDNPSR1GLA | |
| SCHEMBL14393303 | 0.72 | CA1 (0.61) | SMN1; SMN2HTTL3MBTL1CA12CA1 | |
| SCHEMBL24748595 | 0.71 | KDM4E (0.38) | KDM4ESMN1; SMN2CYP3A4MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11981673-B1 | 7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7 tricarboxylates as adenosine receptor active compounds | King Faisal University (SA) | 2024-05-14 | — | — | US | claimed |
| US-11981674-B1 | 7-isopropyl 1-ethyl/methyl 3-(substituted benzoyl)-2-substituted indolizine-1,7-dicarboxylates as larvicidal agents | King Faisal University (SA) | 2024-05-14 | — | — | US | claimed |
| US-11807640-B1 | 7-isopropyl 1-ethyl/methyl 3-(substituted benzoyl)-2-substituted indolizine-1,7-dicarboxylates as anti-tubercular agents | King Faisal University (SA) | 2023-11-07 | — | — | US | claimed |
| US-11981674-B1 | 7-isopropyl 1-ethyl/methyl 3-(substituted benzoyl)-2-substituted indolizine-1,7-dicarboxylates as larvicidal agents | King Faisal University (SA) | 2024-05-14 | — | — | US | disclosed |
| US-11981673-B1 | 7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7 tricarboxylates as adenosine receptor active compounds | King Faisal University (SA) | 2024-05-14 | — | — | US | disclosed |
| US-11807640-B1 | 7-isopropyl 1-ethyl/methyl 3-(substituted benzoyl)-2-substituted indolizine-1,7-dicarboxylates as anti-tubercular agents | King Faisal University (SA) | 2023-11-07 | — | — | US | disclosed |
| US-11807640-B1 | 7-isopropyl 1-ethyl/methyl 3-(substituted benzoyl)-2-substituted indolizine-1,7-dicarboxylates as anti-tubercular agents | King Faisal University (SA) | 2023-11-07 | — | — | US | disclosed |
| US-11807640-B1 | 7-isopropyl 1-ethyl/methyl 3-(substituted benzoyl)-2-substituted indolizine-1,7-dicarboxylates as anti-tubercular agents | King Faisal University (SA) | 2023-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11981674-B1 | 7-isopropyl 1-ethyl/methyl 3-(substituted benzoyl)-2-substituted indolizine-1,7-dicarboxylates as larvicidal agents | CASP7, CASP3, CASP2 | KDM4E 222/4885SMN1; SMN2 2012/4885HPGD 3135/4885 |
| US-11981673-B1 | 7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7 tricarboxylates as adenosine receptor active compounds | ADORA3, ADORA2A, ADORA1 | KDM4E 3478/4885SMN1; SMN2 3897/4885HPGD 3754/4885 |
| US-11807640-B1 | 7-isopropyl 1-ethyl/methyl 3-(substituted benzoyl)-2-substituted indolizine-1,7-dicarboxylates as anti-tubercular agents | IRF3, TBK1, TBKBP1 | KDM4E 745/4885SMN1; SMN2 4739/4885HPGD 1896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.