Sugi Predict

Sugi Predict / Compounds / SCHEMBL26667147

SCHEMBL26667147

SCHEMBL26667147

c1ccc(NC2(C3CC3)CC2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR5A2 O00482 5/20 0.41
▸ NR5A1 Q13285 4/20 0.41
▸ NPFFR1 Q9GZQ6 2/20 0.35
▸ NPFFR2 Q9Y5X5 2/20 0.35
▸ ALDH1A1 P00352 4/20 0.35
▸ TDP1 Q9NUW8 3/20 0.35
▸ HSD17B10 Q99714 2/20 0.35
▸ CTSD P07339 1/20 0.35
▸ MAPT P10636 2/20 0.34
▸ TSHR P16473 2/20 0.33
▸ PTGS2 P35354 2/20 0.33
▸ DDB1 Q16531 1/20 0.33
▸ CRBN Q96SW2 1/20 0.33
▸ TRPA1 O75762 1/20 0.33
▸ ALOX15 P16050 1/20 0.33
▸ ALOX12 P18054 1/20 0.33
▸ PTGS1 P23219 1/20 0.33
▸ SLC6A2 P23975 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ HTR2B P41595 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23674236 0.75 NR5A2 (0.47) NR5A2NR5A1ALDH1A1SLC6A2LMNA
SCHEMBL7702976 0.74 NR5A2 (0.42) NR5A2NR5A1TRPA1SMN1; SMN2HPGD
SCHEMBL23023085 0.69 OPRM1 (0.41) ALDH1A1TDP1MAPTOPRM1OPRL1
SCHEMBL6846932 0.67 ALOX5AP (0.43) NR5A2NR5A1ALDH1A1MAPTDDB1
SCHEMBL8518650 0.67 TDP1 (0.43) NR5A2NR5A1NPFFR1NPFFR2ALDH1A1
SCHEMBL8058024 0.67 CYP2C9 (0.39) NR5A2NR5A1ALDH1A1TDP1MAPT
SCHEMBL6533939 0.66 TRPA1 (0.38) NR5A2NR5A1ALDH1A1MAPTTSHR
SCHEMBL16448226 0.65 TDP1 (0.42) NR5A2ALDH1A1TDP1HSD17B10CTSD
Hydrochloric Acid SCHEMBL27891553 0.65 TDP1 (0.42) ALDH1A1TDP1HSD17B10CTSDMAPT
SCHEMBL8019111 0.64 HTR2B (0.39) ALDH1A1TDP1HSD17B10CTSDHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250074875-A1 AT2R ANTAGONISTS AND USES THEREOF ELI LILLY AND COMPANY 2025-03-06 — — US disclosed
US-12122750-B2 AT2R antagonists and uses thereof ELI LILLY AND COMPANY (US) 2024-10-22 — — US disclosed
US-20230373919-A1 AT2R ANTAGONISTS AND USES THEREOF ELI LILLY AND COMPANY 2023-11-23 — — US disclosed
US-20230373919-A1 AT2R ANTAGONISTS AND USES THEREOF ELI LILLY AND COMPANY 2023-11-23 — — US disclosed
US-20230373919-A1 AT2R ANTAGONISTS AND USES THEREOF ELI LILLY AND COMPANY 2023-11-23 — — US disclosed
WO-2023224853-A1 AT2R ANTAGONISTS AND USES THEREOF ELI LILLY AND COMPANY (US) 2023-11-23 — — WO disclosed
WO-2023224853-A1 AT2R ANTAGONISTS AND USES THEREOF ELI LILLY AND COMPANY (US) 2023-11-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230373919-A1 AT2R ANTAGONISTS AND USES THEREOF AGTR2, AGTR1, AVPR2 NR5A2 565/4885NR5A1 1962/4885NPFFR1 81/4885
US-20250074875-A1 AT2R ANTAGONISTS AND USES THEREOF AGTR2, AGTR1, AVPR2 NR5A2 551/4885NR5A1 1934/4885NPFFR1 84/4885
US-12122750-B2 AT2R antagonists and uses thereof AGTR2, AGTR1, AVPR2 NR5A2 565/4885NR5A1 1962/4885NPFFR1 81/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.