Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.34 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23214479 | 0.76 | ALDH1A1 (0.45) | KMT2AALDH1A1KDM4EMEN1 | |
| SCHEMBL31700182 | 0.76 | ADORA1 (0.43) | ADORA1KMT2AGABRG2GABRB3GABRA5 | |
| SCHEMBL26684272 | 0.75 | GABRG2 (0.34) | KMT2AGABRG2GABRB3GABRA5HPGD | |
| SCHEMBL26684492 | 0.75 | LMNA (0.45) | ADORA1KMT2AGABRG2GABRB3GABRA5 | |
| SCHEMBL26684195 | 0.74 | TARBP2 (0.37) | ADORA1KMT2AALDH1A1KDM4EMEN1 | |
| SCHEMBL12866909 | 0.72 | ADORA1 (0.42) | ADORA1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL23099065 | 0.70 | ADORA3 (0.41) | ADORA3ADORA2AADORA1KMT2AALDH1A1 | |
| SCHEMBL26849845 | 0.68 | PARP1 (0.31) | ADORA2AADORA1HRH3 | |
| SCHEMBL9963424 | 0.68 | DRD3 (0.49) | HPGDGABRA1GABRA2CYP1A2HRH3 | |
| SCHEMBL21033498 | 0.66 | SMO (0.47) | ADORA3ADORA2AADORA1KMT2AGABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250282785-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2025-09-11 | — | — | US | disclosed |
| EP-4522608-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN Pharmaceutica NV (BE) | 2025-03-19 | — | — | EP | disclosed |
| CN-119546602-A | Pyrrolidone derivatives as inhibitors of nfkb-induced kinase | 詹森药业有限公司 | 2025-02-28 | — | — | CN | disclosed |
| WO-2023217906-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250282785-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | NFKBIA, IKBKG, IKBKB | ADORA3 4710/4885ADORA2A 4485/4885ADORA1 4523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.