Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.80 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL4444183 | 1.00 | ALDH1A1 (0.80) | ALDH1A1TSHRTTR | |
| Tetrahydrofuran SCHEMBL1361999 | 1.00 | — | — | |
| Tetrahydrofuran SCHEMBL1005228 | 0.95 | ALDH1A1 (0.89) | ALDH1A1TSHRTTR | |
| Tetrahydrofuran SCHEMBL1450115 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TSHRTTR | |
| Tetrahydrofuran SCHEMBL22129675 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TSHRTTR | |
| Tetrahydrofuran SCHEMBL6361564 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TSHRTTR | |
| Tetrahydrofuran SCHEMBL6345343 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TSHRTTR | |
| Tetrahydrofuran SCHEMBL22230565 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TSHRTTR | |
| Tetrahydrofuran SCHEMBL18729662 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL4076453 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 546 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116063217-B | Efficient catalyst ligand for ethylene selective trimerization, preparation method, catalyst system and application thereof | 海南贝欧亿科技有限公司 | 2025-01-10 | — | — | CN | claimed |
| EP-3907003-B1 | HALOGEN-CONTAINING COMPOUND AND USE THEREOF AS CATALYST LIGAND IN ETHYLENE OLIGOMERIZATION | CHINA PETROLEUM & CHEM CORP (CN) | 2024-09-04 | — | — | EP | claimed |
| CN-114891037-B | Catalyst ligand and preparation method thereof, catalyst ligand complex and preparation method thereof | 海南贝欧亿科技有限公司 | 2024-08-16 | — | — | CN | claimed |
| US-12037301-B1 | Chromium-catalyzed ethylene oligomerization with bulky functionalized N-aryl bisphosphineamine ligands | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2024-07-16 | — | — | US | claimed |
| WO-2024136928-A1 | CHROMIUM-CATALYZED ETHYLENE OLIGOMERIZATION WITH BULKY FUNCTIONALIZED N-ARYL BISPHOSPHINEAMINE LIGANDS | SAUDI ARABIAN OIL COMPANY (SA) | 2024-06-27 | — | — | WO | claimed |
| US-20240208882-A1 | CHROMIUM-CATALYZED ETHYLENE OLIGOMERIZATION WITH BULKY FUNCTIONALIZED N-ARYL BISPHOSPHINEAMINE LIGANDS | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2024-06-27 | — | — | US | claimed |
| US-11925927-B2 | Ligands for production of 1-octene in chromium assisted ethylene oligomerization process | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2024-03-12 | — | — | US | claimed |
| WO-2024049820-A1 | CATALYST SYSTEMS THAT INCLUDE META-ALKOXY SUBSTITUTED N-ARYL BIS-DIPHOSPHINOAMINE LIGANDS | SAUDI ARABIAN OIL COMPANY (SA) | 2024-03-07 | — | — | WO | claimed |
| EP-4294564-A1 | CATALYST SYSTEMS | Saudi Arabian Oil Company (SA) | 2023-12-27 | — | — | EP | claimed |
| CN-117263977-A | Catalyst ligand for ethylene selective oligomerization, preparation method thereof and catalyst for ethylene selective oligomerization | 海南贝欧亿科技有限公司 | 2023-12-22 | — | — | CN | claimed |
| US-20060229480-A1 | Tetramerization of olefins | SASOL TECHNOLOGY (PTY) LIMITED (ZA) | 2006-10-12 | — | — | US | claimed |
| US-20060211903-A1 | Trimerisation of olefins | SASOL TECHNOLOGY (PTY) LIMITED (ZA) | 2006-09-21 | — | — | US | claimed |
| US-20060173226-A1 | Tetramerization of olefins | SASOL TECHNOLOGY (PTY) LIMITED (ZA) | 2006-08-03 | — | — | US | claimed |
| US-20060128910-A1 | Tandem tetramerisation-polymerisation of olefins | SASOL TECHNOLOGY (PTY) LIMITED (ZA) | 2006-06-15 | — | — | US | claimed |
| EP-1581341-A1 | TRIMERISATION OF OLEFINS | Sasol Technology (Pty) Ltd (ZA) | 2005-10-05 | — | — | EP | claimed |
| EP-1581342-A1 | TETRAMERIZATION OF OLEFINS | Sasol Technology (Proprietary) Limited (ZA) | 2005-10-05 | — | — | EP | claimed |
| EP-1578531-A1 | TETRAMERIZATION OF OLEFINS | Sasol Technology (PTY) Limited (ZA) | 2005-09-28 | — | — | EP | claimed |
| WO-2004056479-A1 | TETRAMERIZATION OF OLEFINS | SASOL TECHNOLOGY (PTY) LTD (ZA) | 2004-07-08 | — | — | WO | claimed |
| WO-2004056478-A1 | TETRAMERIZATION OF OLEFINS | SASOL TECHNOLOGY (PTY) LIMITED (ZA) | 2004-07-08 | — | — | WO | claimed |
| WO-2004056477-A1 | TRIMERISATION OF OLEFINS | SASOL TECHNOLOGY (PTY) LIMITED (ZA) | 2004-07-08 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208882-A1 | CHROMIUM-CATALYZED ETHYLENE OLIGOMERIZATION WITH BULKY FUNCTIONALIZED N-ARYL BISPHOSPHINEAMINE LIGANDS | C1S, C9, C5 | ALDH1A1 3821/4885TSHR 340/4885TTR 1160/4885 |
| US-12037301-B1 | Chromium-catalyzed ethylene oligomerization with bulky functionalized N-aryl bisphosphineamine ligands | C1S, C9, C5 | ALDH1A1 3821/4885TSHR 340/4885TTR 1160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.