Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.80 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL1450115 | 1.00 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL1005228 | 0.95 | ALDH1A1 (0.89) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL267714 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL22230565 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL6361564 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL18729662 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL4076453 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL22129675 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL1361999 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL4444183 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119080830-A | Tetrahydronaphthol-phosphine pre-transition metal complex, and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-12-06 | — | — | CN | claimed |
| CN-118619992-A | Phosphine-phenol transition metal organic complex, and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-09-10 | — | — | CN | claimed |
| CN-117866002-A | Phosphine-phenol transition metal complex and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-04-12 | — | — | CN | claimed |
| CN-119798491-A | Coordination precipitation polymerization process for olefin polymerization and polyolefin | 中国石油化工股份有限公司 | 2025-04-11 | — | — | CN | disclosed |
| CN-119661750-A | Coordination precipitation polymerization process for olefin polymerization and polyolefin | 中国石油化工股份有限公司 | 2025-03-21 | — | — | CN | disclosed |
| CN-119080830-A | Tetrahydronaphthol-phosphine pre-transition metal complex, and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-12-06 | — | — | CN | disclosed |
| CN-118619992-A | Phosphine-phenol transition metal organic complex, and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-09-10 | — | — | CN | disclosed |
| CN-117866002-A | Phosphine-phenol transition metal complex and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-04-12 | — | — | CN | disclosed |
| CN-111909196-B | IVB-group-containing bimetallic complex catalyst, and preparation method and application thereof | 万华化学集团股份有限公司 | 2023-05-26 | — | — | CN | disclosed |
| CN-111848668-B | Pyridinylamino IVB group binuclear metal complex and preparation and application thereof | 万华化学集团股份有限公司 | 2023-03-03 | — | — | CN | disclosed |
| CN-112358498-B | Tetraaryloxy IVB group binuclear metal complex and preparation and application thereof | 万华化学集团股份有限公司 | 2023-03-03 | — | — | CN | disclosed |
| US-20120183435-A1 | NANOWIRE PREPARATION METHODS, COMPOSITIONS, AND ARTICLES | CARESTREAM HEALTH, INC. | 2012-07-19 | — | — | US | disclosed |
| US-20120183434-A1 | NANOWIRE PREPARATION METHODS, COMPOSITIONS, AND ARTICLES | TROPHY DENTAL INC. | 2012-07-19 | — | — | US | disclosed |
| WO-2012096754-A1 | NANOWIRE PREPARATION METHODS, COMPOSITIONS, AND ARTICLES | CARESTREAM HEALTH, INC. (US) | 2012-07-19 | — | — | WO | disclosed |
| US-20120148436-A1 | NANOWIRE PREPARATION METHODS, COMPOSITIONS, AND ARTICLES | CARESTREAM HEALTH, INC. | 2012-06-14 | — | — | US | disclosed |
| WO-2012078273-A2 | NANOWIRE PREPARATION METHODS, COMPOSITIONS, AND ARTICLES | CARESTREAM HEALTH, INC. (US) | 2012-06-14 | — | — | WO | disclosed |
| US-8198497-B2 | Oligomerization catalyst; zirconium tetrachloride diphenylsulfone; zirconium tetrachloride diethylsulfone | POLIMERI EUROPA S.P.A. (IT) | 2012-06-12 | — | — | US | disclosed |
| US-20050070425-A1 | Catalytic composition and process for the selective oligomerization of ethylene to light linear alpha-olefins | POLIMERI EUROPA S.P.A (IT) | 2005-03-31 | — | — | US | disclosed |
| EP-1453604-A2 | CATALYTIC COMPOSITION AND PROCESS FOR THE SELECTIVE OLIGOMERIZATION OF ETHYLENE TO LIGHT LINEAR ALPHA-OLEFINS | Polimeri Europa S.r.l. (IT) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003053573-A2 | CATALYTIC COMPOSITION AND PROCESS FOR THE SELECTIVE OLIGOMERIZATION OF ETHYLENE TO LIGHT LINEAR ALPHA-OLEFINS | POLIMERI EUROPA S.P.A. (IT) | 2003-07-03 | — | — | WO | disclosed |