Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GNRHR | P30968 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6018477 | 0.96 | MEN1 (0.35) | MEN1KMT2AMAPTKDM4APOLB | |
| SCHEMBL27699697 | 0.93 | KMT2A (0.37) | MEN1KMT2AMAPTKDM4APOLB | |
| SCHEMBL16696040 | 0.86 | KMT2A (0.35) | MEN1KMT2AMAPTKDM4APOLB | |
| SCHEMBL15624033 | 0.85 | MEN1 (0.36) | MEN1KMT2AMAPTKDM4APOLB | |
| SCHEMBL23724052 | 0.84 | APEX1 (0.36) | MEN1KMT2AMAPTKDM4APOLB | |
| SCHEMBL1065475 | 0.84 | APEX1 (0.36) | MEN1KMT2AMAPTKDM4APOLB | |
| SCHEMBL997083 | 0.84 | — | — | |
| SCHEMBL3868601 | 0.83 | GNRHR (0.39) | MEN1KMT2AMAPTKDM4APOLB | |
| SCHEMBL17838804 | 0.83 | GNRHR (0.39) | MEN1KMT2AMAPTKDM4APOLB | |
| SCHEMBL608262 | 0.83 | MAPT (0.36) | MEN1KMT2AMAPTKDM4APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934202-B1 | NICOTINIC ACID AND PICOLINIC ACID DERIVED NEAR-INFRARED FLUOROPHORES | VISEN MEDICAL INC (US) | 2019-01-09 | — | — | EP | disclosed |
| EP-2912464-B1 | HYDROXAMATE SUBSTITUTED AZAINDOLINE-CYANINE DYES AND BIOCONJUGATES OF THE SAME | BECTON DICKINSON CO (US) | 2017-04-26 | — | — | EP | disclosed |
| EP-2758475-B1 | DYES FOR LABELLING MOLECULAR LIGANDS | ILLUMINA CAMBRIDGE LTD (GB) | 2017-04-26 | — | — | EP | disclosed |
| US-20160176819-A1 | ASYMMETRICALLY CHARGED NIR FLUOROPHORES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-06-23 | — | — | US | disclosed |
| US-8771646-B2 | Nicotinic acid and picolinic acid derived near-infrared fluorophores | VISEN MEDICAL, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20130272967-A1 | Nicotinic Acid and Picolinic Acid Derived Near-Infrared Fluorophores | VISEN MEDICAL, INC. | 2013-10-17 | — | — | US | disclosed |
| US-8455651-B2 | Nicotinic acid and picolinic acid derived near-infrared fluorophores | VISEN MEDICAL, INC. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20120321562-A1 | NICOTINIC ACID AND PICOLINIC ACID DERIVED NEAR-INFRARED FLUOROPHORES | VISEN MEDICAL, INC. | 2012-12-20 | — | — | US | disclosed |
| US-8173819-B2 | Nicotinic and picolinic acid derived near-infrared fluorophores | VISEN MEDICAL, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| US-20080267883-A1 | Comprises carboxyl or carbonyl functionalized pyridine moiety; bioconjugation; biocompatability; in vivo optical imaging | VISEN MEDICAL, INC. | 2008-10-30 | — | — | US | disclosed |
| EP-1934202-A2 | NICOTINIC ACID AND PICOLINIC ACID DERIVED NEAR-INFRARED FLUOROPHORES | Visen Medical, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007028118-A2 | NICOTINIC ACID AND PICOLINIC ACID DERIVED NEAR-INFRARED FLUOROPHORES | VISEN MEDICAL, INC. (US) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120321562-A1 | NICOTINIC ACID AND PICOLINIC ACID DERIVED NEAR-INFRARED FLUOROPHORES | NAPRT, NAMPT, HCAR2 | MEN1 2144/4885KMT2A 4156/4885MAPT 1101/4885 |
| US-20130272967-A1 | Nicotinic Acid and Picolinic Acid Derived Near-Infrared Fluorophores | NAPRT, NAMPT, HCAR2 | MEN1 2144/4885KMT2A 4156/4885MAPT 1101/4885 |
| US-20160176819-A1 | ASYMMETRICALLY CHARGED NIR FLUOROPHORES | CRY2, PARP15, CRY1 | MEN1 2399/4885KMT2A 2054/4885MAPT 3307/4885 |
| US-20080267883-A1 | Comprises carboxyl or carbonyl functionalized pyridine moiety; bioconjugation; biocompatability; in vivo optical imaging | PAICS, PC, CBR3 | MEN1 1959/4885KMT2A 4448/4885MAPT 3127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.