SCHEMBL26798432

SCHEMBL26798432

O=C(Nc1ccc2ccccc2c1)Nc1ncnc2[nH]c(=O)[nH]c12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.51
▸ NPC1 O15118 2/20 0.51
▸ RAB9A P51151 1/20 0.51
▸ CA2 P00918 2/20 0.47
▸ KDR P35968 2/20 0.46
▸ CA12 O43570 1/20 0.45
▸ CA1 P00915 1/20 0.45
▸ CA9 Q16790 1/20 0.45
▸ BRAF P15056 5/20 0.45
▸ FLT1 P17948 1/20 0.45
▸ TEK Q02763 1/20 0.45
▸ RIPK1 Q13546 1/20 0.45
▸ MEN1 O00255 3/20 0.44
▸ KMT2A Q03164 3/20 0.44
▸ POLB P06746 2/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.44
▸ ALDH1A1 P00352 1/20 0.44
▸ HTT P42858 1/20 0.44
▸ NPSR1 Q6W5P4 1/20 0.44
▸ KIT P10721 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26778638 0.85 ADORA3 (0.55) NPC1RAB9AKDRBRAFHTT
SCHEMBL26778942 0.79 MAPT (0.46) MAPTNPC1RAB9ACA2KDR
SCHEMBL26779010 0.79 BRAF (0.47) MAPTNPC1RAB9ACA2KDR
SCHEMBL26778927 0.77 MAPT (0.44) MAPTNPC1RAB9ACA2KDR
SCHEMBL22425113 0.74 MAPT (0.62) MAPTNPC1RAB9ACA2MEN1
SCHEMBL9547503 0.74 RAB9A (0.89) MAPTNPC1RAB9ACA2KDR
SCHEMBL26779024 0.74 SLC6A5 (0.40) MAPTNPC1RAB9AKDRBRAF
SCHEMBL26779045 0.70 SLC6A5 (0.42) MAPTNPC1RAB9ABRAFPOLB
SCHEMBL30697002 0.70 MAPT (1.00) MAPTNPC1RAB9ACA2KDR
SCHEMBL11049543 0.70 MAPT (1.00) MAPTNPC1RAB9ACA2KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023220428-A1 COMPOSITIONS FOR EDITING ASS1 TRANSCRIPTS AND METHODS THEREOF WAVE LIFE SCIENCES LTD. (SG) 2023-11-16 — — WO disclosed
WO-2023220440-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF WAVE LIFE SCIENCES LTD. (SG) 2023-11-16 — — WO disclosed
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