Sugi Predict

Sugi Predict / Compounds / SCHEMBL2680211

SCHEMBL2680211

SCHEMBL2680211

Cc1cc(S(=O)(=O)NC(=O)c2cn3cc(C(F)(F)F)cc(Cl)c3n2)c(C)cc1C#N

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 4/20 0.36
▸ NFKB1 P19838 4/20 0.36
▸ RAB9A P51151 4/20 0.36
▸ NFKB2 Q00653 4/20 0.36
▸ RELA Q04206 4/20 0.36
▸ SMN1; SMN2 Q16637 4/20 0.36
▸ MAPT P10636 2/20 0.36
▸ LMNA P02545 2/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ CYP3A4 P08684 1/20 0.35
▸ CYP2C9 P11712 1/20 0.35
▸ CYP2C19 P33261 1/20 0.35
▸ RECQL P46063 1/20 0.35
▸ KDM4E B2RXH2 2/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ P2RY12 Q9H244 2/20 0.34
▸ PKM P14618 1/20 0.33
▸ SCN9A Q15858 2/20 0.33
▸ LRRK2 Q5S007 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10264532 0.88 RXFP1 (0.34) LMNAKDM4EALDH1A1
SCHEMBL2680349 0.81 NPC1 (0.39) NPC1NFKB1RAB9ANFKB2RELA
SCHEMBL2680314 0.81 ALDH1A1 (0.41) NPC1NFKB1RAB9ANFKB2RELA
SCHEMBL2680796 0.80 NPC1 (0.39) NPC1NFKB1RAB9ANFKB2RELA
SCHEMBL2681457 0.79 NPC1 (0.39) NPC1NFKB1RAB9ANFKB2RELA
SCHEMBL10204206 0.78 NFKB1 (0.40) NPC1NFKB1RAB9ANFKB2RELA
SCHEMBL2682591 0.78 HTT (0.39) NPC1NFKB1RAB9ANFKB2RELA
SCHEMBL2681107 0.77 NPC1 (0.40) NPC1NFKB1RAB9ANFKB2RELA
SCHEMBL2680256 0.77 SMN1; SMN2 (0.40) NPC1NFKB1RAB9ANFKB2RELA
SCHEMBL10204201 0.77 NFKB1 (0.39) NPC1NFKB1RAB9ANFKB2RELA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2427058-B1 NEMATOCIDAL SULFONAMIDES DU PONT (US) 2014-12-31 — — EP claimed
US-20140221203-A1 NEMATOCIDAL SULFONAMIDES E I DU PONT DE NEMOURS AND COMPANY (US) 2014-08-07 — — US claimed
US-8623890-B2 Nematocidal sulfonamides E I DU PONT DE NEMOURS AND COMPANY (US) 2014-01-07 — — US claimed
US-20120114624-A1 NEMATOCIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2012-05-10 — — US claimed
US-9868719-B2 Compounds with pesticidal activity BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-01-16 — — US disclosed
EP-3024330-B1 IMIDAZOTHIA(DIA)ZOLE SULFONAMIDES AS NEMATICIDES BAYER CROPSCIENCE AG (DE) 2017-08-30 — — EP disclosed
EP-3039018-B1 PYRIDYL CARBOXAMIDE DERIVATIVES WITH PESTICIDAL ACTIVITY BAYER CROPSCIENCE AG (DE) 2017-08-02 — — EP disclosed
US-9512144-B2 Imidazothiazole sufonamides as nematicides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-12-06 — — US disclosed
US-20160198708-A1 COMPOUNDS WITH PESTICIDAL ACTIVITY BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-07-14 — — US disclosed
US-20160176898-A1 IMIDAZOTHIAZOLE SUFONAMIDES AS NEMATICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-06-23 — — US disclosed
US-20160159805-A1 Heterocyclic sulfonylamino(thio)carbonyl-derivatives with nematicidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-06-09 — — US disclosed
EP-3024330-A1 IMIDAZOTHIA(DIA)ZOLE SULFONAMIDES AS NEMATICIDES Bayer CropScience Aktiengesellschaft (DE) 2016-06-01 — — EP disclosed
US-20140088309-A1 NEMATOCIDAL SULFONAMIDES E I DU PONT DE NEMOURS AND COMPANY (US) 2014-03-27 — — US disclosed
US-8623890-B2 Nematocidal sulfonamides E I DU PONT DE NEMOURS AND COMPANY (US) 2014-01-07 — — US disclosed
US-8623890-B2 Nematocidal sulfonamides E I DU PONT DE NEMOURS AND COMPANY (US) 2014-01-07 — — US disclosed
US-8623890-B2 Nematocidal sulfonamides E I DU PONT DE NEMOURS AND COMPANY (US) 2014-01-07 — — US disclosed
US-20120114624-A1 NEMATOCIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2012-05-10 — — US disclosed
US-20120114624-A1 NEMATOCIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2012-05-10 — — US disclosed
US-20120114624-A1 NEMATOCIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2012-05-10 — — US disclosed
WO-2010129500-A2 NEMATOCIDAL SULFONAMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2010-11-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160159805-A1 Heterocyclic sulfonylamino(thio)carbonyl-derivatives with nematicidal properties TST, TUBB, TUBA3C NPC1 1872/4885NFKB1 2034/4885RAB9A 1352/4885
US-20140221203-A1 NEMATOCIDAL SULFONAMIDES NSFL1C, QSOX1, Q6ZSR9 NPC1 1818/4885NFKB1 1493/4885RAB9A 1511/4885
US-20120114624-A1 NEMATOCIDAL SULFONAMIDES NSFL1C, QSOX1, Q6ZSR9 NPC1 1818/4885NFKB1 1493/4885RAB9A 1511/4885
US-20140088309-A1 NEMATOCIDAL SULFONAMIDES NSFL1C, QSOX1, Q6ZSR9 NPC1 1818/4885NFKB1 1493/4885RAB9A 1511/4885
US-20160176898-A1 IMIDAZOTHIAZOLE SUFONAMIDES AS NEMATICIDES NISCH, TST, SULT1E1 NPC1 2009/4885NFKB1 4541/4885RAB9A 1772/4885
US-20160198708-A1 COMPOUNDS WITH PESTICIDAL ACTIVITY ACHE, DDT, CAT NPC1 2460/4885NFKB1 2487/4885RAB9A 1117/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.