SCHEMBL268261

SCHEMBL268261

N[C@@H](Cc1cn(OC=O)cn1)C(=O)Oc1nccc2ccccc12

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KLK5 Q9Y337 1/20 0.34
▸ FFAR1 O14842 1/20 0.33
▸ SSTR1 P30872 1/20 0.32
▸ SSTR4 P31391 1/20 0.32
▸ NCOA3 Q9Y6Q9 1/20 0.32
▸ ACACB O00763 1/20 0.32
▸ HDAC3 O15379 1/20 0.31
▸ HDAC4 P56524 1/20 0.31
▸ HDAC1 Q13547 1/20 0.31
▸ HDAC7 Q8WUI4 1/20 0.31
▸ HDAC2 Q92769 1/20 0.31
▸ HDAC10 Q969S8 1/20 0.31
▸ HDAC11 Q96DB2 1/20 0.31
▸ HDAC8 Q9BY41 1/20 0.31
▸ HDAC6 Q9UBN7 1/20 0.31
▸ HDAC9 Q9UKV0 1/20 0.31
▸ HDAC5 Q9UQL6 1/20 0.31
▸ CPB1 P15086 1/20 0.30
▸ CPB2 Q96IY4 1/20 0.30
▸ ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4976535 0.85 FFAR1 (0.37) KLK5FFAR1SSTR1SSTR4NCOA3
SCHEMBL28114917 0.73 FFAR1 (0.42) KLK5FFAR1SSTR1SSTR4NCOA3
SCHEMBL4308250 0.71 NLN (0.53) —
SCHEMBL28967691 0.67 LMNA (0.50) KLK5FFAR1SSTR1SSTR4NCOA3
SCHEMBL2230387 0.66 KLK5 (0.49) KLK5FFAR1SSTR1SSTR4NCOA3
SCHEMBL4353465 0.65 KLK5 (0.51) KLK5FFAR1SSTR1SSTR4NCOA3
SCHEMBL231952 0.65 KLK5 (0.51) KLK5FFAR1SSTR1SSTR4NCOA3
SCHEMBL761986 0.64 KLK5 (0.50) KLK5FFAR1SSTR1SSTR4NCOA3
SCHEMBL27220785 0.64 KLK5 (0.53) KLK5FFAR1SSTR1SSTR4NCOA3
SCHEMBL7950368 0.63 CPB2 (0.35) CPB1CPB2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 564 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6338945-B1 CONCURRENT SCREENING OF OLIGOPEPTIDE LIBRARIES SYNTHESIZED ON SOLID PHASE SUPPORTS TO ISOLATE BIOACTIVE MOLECULES WHICH ELICIT CYTOLYTIC ACTIVITY GENZYME CORPORATION 2002-01-15 — — US claimed
US-20240189401-A1 UNIT DOSE FORMULATION OF ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME ALEXION PHARMA INC (US) 2024-06-13 — — US disclosed
CN-113727990-B Short synthetic peptides and their use for the treatment of retinal degenerative diseases and/or tissue damage 曹友平 2024-05-28 — — CN disclosed
US-20240082367-A1 ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME ALEXION PHARMA INC (US) 2024-03-14 — — US disclosed
WO-2024035929-A2 INSULIN SENSITIZERS FOR REVERSAL OF INSULIN RESISTANCE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-02-15 — — WO disclosed
US-11859015-B2 Immunogenic WT-1 peptides and methods of use thereof MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2024-01-02 — — US disclosed
US-11839646-B2 Antidotes for factor Xa inhibitors and methods of using the same ALEXION PHARMACEUTICALS, INC. (US) 2023-12-12 — — US disclosed
US-20230265122-A1 IMMUNOGENIC WT-1 PEPTIDES AND METHODS OF USE THEREOF MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2023-08-24 — — US disclosed
CN-115920017-A Methods and compositions for treating cancer 纪念斯隆凯特林癌症中心 2023-04-07 — — CN disclosed
CN-110078813-B Immunogenic WT-1 peptides and methods of use thereof 纪念斯隆凯特林癌症中心 2023-03-28 — — CN disclosed
WO-1998038312-A1 BACTERIAL ELASTIN BINDING PROTEIN, NUCLEIC ACID SEQUENCE ENCODING SAME AND DIAGNOSTIC AND THERAPEUTIC METHODS OF USE THEREOF WASHINGTON UNIVERSITY (US) 1998-09-03 — — WO disclosed
US-5650489-A SOLID PHASE SYNTHESIS OF PEPTIDES, RANDOM SEQUENCES, COMBINATORIAL CHEMISTRY THE ARIZONA BOARD OF REGENTS (US) 1997-07-22 — — US disclosed
US-5510240-A Method of screening a peptide library THE ARIZONA BOARD OF REGENTS (US) 1996-04-23 — — US disclosed
EP-0705279-A1 TOPOLOGICALLY SEGREGATED, ENCODED SOLID PHASE LIBRARIES SELECTIDE CORPORATION (US) 1996-04-10 — — EP disclosed
US-5470753-A Peptide sequencing using mass spectrometry SELECTIDE CORPORATION (US) 1995-11-28 — — US disclosed
WO-1994028028-A1 TOPOLOGICALLY SEGREGATED, ENCODED SOLID PHASE LIBRARIES SELECTIDE CORPORATION (US) 1994-12-08 — — WO disclosed
WO-1994006017-A1 PEPTIDE SEQUENCING USING MASS SPECTROMETRY SELECTIDE CORPORATION (US) 1994-03-17 — — WO disclosed
EP-0542770-A4 RANDOM BIO-OLIGOMER LIBRARY, A METHOD OF SYNTHESIS THEREOF, AND A METHOD OF USE THEREOF — 1993-09-15 — — EP disclosed
EP-0542770-A1 RANDOM BIO-OLIGOMER LIBRARY, A METHOD OF SYNTHESIS THEREOF, AND A METHOD OF USE THEREOF ARIZONA BOARD OF REGENTS a body corporate acting on behalf of Arizona State University (US) 1993-05-26 — — EP disclosed
WO-1992000091-A1 RANDOM BIO-OLIGOMER LIBRARY, A METHOD OF SYNTHESIS THEREOF, AND A METHOD OF USE THEREOF BIOLIGAND, INC. (US) 1992-01-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240189401-A1 UNIT DOSE FORMULATION OF ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME SERPINC1, F8, F9 KLK5 266/4885FFAR1 4161/4885SSTR1 3242/4885
US-20240082367-A1 ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME SERPINC1, F13B, F2 KLK5 368/4885FFAR1 4654/4885SSTR1 4761/4885
US-11839646-B2 Antidotes for factor Xa inhibitors and methods of using the same SERPINC1, F13B, HABP2 KLK5 311/4885FFAR1 4683/4885SSTR1 4748/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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