Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 3/20 | 0.45 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26889371 | 1.00 | CCNK (0.45) | CCNKCDK12CHEK1METAP2NPC1 | |
| SCHEMBL26889381 | 0.87 | CCNK (0.54) | CCNKCDK12METAP2POLB | |
| SCHEMBL26889405 | 0.86 | DRD2 (0.46) | CCNKCDK12CHEK1CDC7PIM1 | |
| SCHEMBL26686575 | 0.86 | CCNK (0.58) | CCNKCDK12CHEK1METAP2NPC1 | |
| SCHEMBL26889338 | 0.86 | CCNK (0.58) | CCNKCDK12METAP2POLBCDC7 | |
| SCHEMBL26889438 | 0.84 | HRH3 (0.44) | CDC7PIM1CDK9DRD2DRD4 | |
| SCHEMBL26889310 | 0.84 | CCNK (0.42) | CCNKCDK12CDC7PIM1CDK9 | |
| SCHEMBL26889354 | 0.83 | CCNK (0.45) | CCNKCDK12METAP2CDC7PIM1 | |
| SCHEMBL16809638 | 0.78 | METAP2 (0.41) | CHEK1METAP2NPC1POLBSMN1; SMN2 | |
| SCHEMBL31240929 | 0.77 | CDK9 (0.49) | CHEK1METAP2NPC1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023218201-A1 | IKK INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2023-11-16 | — | — | WO | disclosed |