Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 1/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.65 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | CASR | P41180 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29447439 | 1.00 | SLC22A1 (0.65) | SLC22A1OPRM1AOC3SLC6A2SLC6A4 | |
| SCHEMBL30248352 | 1.00 | SLC22A1 (0.65) | SLC22A1OPRM1AOC3SLC6A2SLC6A4 | |
| SCHEMBL2323271 | 1.00 | SLC22A1 (0.65) | SLC22A1OPRM1AOC3SLC6A2SLC6A4 | |
| SCHEMBL670039 | 1.00 | SLC22A1 (0.65) | SLC22A1OPRM1AOC3SLC6A2SLC6A4 | |
| SCHEMBL29447428 | 1.00 | SLC22A1 (0.65) | SLC22A1OPRM1AOC3SLC6A2SLC6A4 | |
| SCHEMBL3898874 | 1.00 | SLC22A1 (0.65) | SLC22A1OPRM1AOC3SLC6A2SLC6A4 | |
| SCHEMBL269430 | 1.00 | SLC22A1 (0.65) | SLC22A1OPRM1AOC3SLC6A2SLC6A4 | |
| SCHEMBL10062052 | 1.00 | SLC22A1 (0.65) | SLC22A1OPRM1AOC3SLC6A2SLC6A4 | |
| SCHEMBL15092674 | 1.00 | SLC22A1 (0.65) | SLC22A1OPRM1AOC3SLC6A2SLC6A4 | |
| SCHEMBL26719465 | 1.00 | SLC22A1 (0.65) | SLC22A1OPRM1AOC3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 251 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807243-B1 | A NOVEL PROCESS FOR THE PREPARATION OF TAPENTADOL | PHARMATHEN SA (GR) | 2024-05-22 | — | — | EP | claimed |
| CN-117447337-A | Tapentadol artificial hapten and artificial antigen as well as preparation methods and application thereof | 杭州同舟生物技术有限公司 | 2024-01-26 | — | — | CN | claimed |
| EP-4269384-A1 | METHOD FOR CRYSTALLIZING TAPENTADOL INTERMEDIATE, TAPENTADOL INTERMEDIATE OF HIGH PURITY, METHOD OF MAKING TAPENTADOL AND TAPENTADOL OF HIGH PURITY | KRKA, d.d., Novo mesto (SI) | 2023-11-01 | — | — | EP | claimed |
| US-20210253513-A1 | A NOVEL PROCESS FOR THE PREPARATION OF TAPENTADOL | PHARMATHEN S.A. (GR) | 2021-08-19 | — | — | US | claimed |
| CN-112262121-A | Novel process for the preparation of tapentadol | 法尔玛赞公司 | 2021-01-22 | — | — | CN | claimed |
| EP-3377049-B1 | CRYSTALLINE FORMS OF TAPENTADOL SALTS AND PROCESS FOR PREPARATION THEREOF | MSN LABORATORIES PRIVATE LTD (IN) | 2021-01-06 | — | — | EP | claimed |
| EP-2606030-B1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | INDOCO REMEDIES LTD (IN) | 2016-05-18 | — | — | EP | claimed |
| US-8853456-B2 | Process for the preparation of tapentadol | INDOCO REMEDIES LIMITED (US) | 2014-10-07 | — | — | US | claimed |
| US-8791300-B2 | Process for preparing a substituted dimethyl-(3-arylbutyl)amine compound by homogeneous catalysis | GRUENENTHAL GMBH (DE) | 2014-07-29 | — | — | US | claimed |
| WO-2013111161-A2 | PROCESS FOR THE PREPARATION OF 3-ARYL-2-METHYL-PROPANAMINE DERIVATIVES AND POLYMORPHS THEREOF | MSN LABORATORIES LIMITED (IN) | 2013-08-01 | — | — | WO | claimed |
| EP-2046726-B1 | PREPARATION OF (2R,3R)-3-(3-METHOXYPHENYL)-N,N,2-TRIMETHYLPENTANAMINE | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-20 | — | — | EP | claimed |
| US-20090312578-A1 | PREPARATION OF (2R,3R)-3-(3-METHOXYPHENYL)-N,N,2-TRIMETHYLPENTANAMINE | JANSSEN PHARMACEUTICA NA (BE) | 2009-12-17 | — | — | US | claimed |
| EP-1633697-B1 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 3-ARYL-BUTYL AMINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-03-11 | — | — | EP | claimed |
| US-20090043132-A1 | Process for Preparing a Substituted Dimethyl-(3-arylbutyl)amine Compound by Homogeneous Catalysis | GRUENENTHAL GMBH (DE) | 2009-02-12 | — | — | US | claimed |
| US-7417170-B2 | Process for the preparation of substituted 3-aryl-butylamine compounds | GRUENENTHAL GMBH (DE) | 2008-08-26 | — | — | US | claimed |
| EP-1943211-A1 | PROCESS FOR PREPARING SUBSTITUTED DIMETHYL(3-ARYLBUTYL)AMINE COMPOUNDS BY MEANS OF HOMOGENEOUS CATALYSIS | Grünenthal GmbH (DE) | 2008-07-16 | — | — | EP | claimed |
| WO-2007051576-A1 | PROCESS FOR PREPARING SUBSTITUTED DIMETHYL(3-ARYLBUTYL)AMINE COMPOUNDS BY MEANS OF HOMOGENEOUS CATALYSIS | Grünenthal GmbH (DE) | 2007-05-10 | — | — | WO | claimed |
| US-20060194988-A1 | Process for the preparation of substitued 3-aryl-butylamine compounds | GRUENENTHAL GMBH | 2006-08-31 | — | — | US | claimed |
| EP-1633697-A1 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 3-ARYL-BUTYL AMINE COMPOUNDS | Grünenthal GmbH (DE) | 2006-03-15 | — | — | EP | claimed |
| WO-2004108658-A1 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 3-ARYL-BUTYL AMINE COMPOUNDS | Grünenthal GmbH (DE) | 2004-12-16 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194988-A1 | Process for the preparation of substitued 3-aryl-butylamine compounds | BRD3, TYR, BBOX1 | SLC22A1 4252/4885OPRM1 131/4885AOC3 46/4885 |
| US-20090312578-A1 | PREPARATION OF (2R,3R)-3-(3-METHOXYPHENYL)-N,N,2-TRIMETHYLPENTANAMINE | PNMT, HTR3A, HTR3C | SLC22A1 4476/4885OPRM1 8/4885AOC3 1614/4885 |
| US-20090043132-A1 | Process for Preparing a Substituted Dimethyl-(3-arylbutyl)amine Compound by Homogeneous Catalysis | HRH3, CAT, CMA1 | SLC22A1 4631/4885OPRM1 1416/4885AOC3 240/4885 |
| US-20210253513-A1 | A NOVEL PROCESS FOR THE PREPARATION OF TAPENTADOL | OPRK1, OPRL1, OPRM1 | SLC22A1 2262/4885OPRM1 3/4885AOC3 1796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.