Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 10/20 | 0.45 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | MLNR | O43193 | 1/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL2697146 | 1.00 | ALDH1A1 (0.46) | ALDH1A1KDM4EHSD17B10SLC6A4SLC6A2 | |
| SCHEMBL2062227 | 0.93 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3KMT2AGAA | |
| SCHEMBL2062229 | 0.93 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3KMT2AGAA | |
| Hydrochloric Acid SCHEMBL15400702 | 0.92 | SLC6A4 (0.49) | SLC6A4SLC6A2SLC6A3KMT2AGAA | |
| Hydrochloric Acid SCHEMBL15400700 | 0.92 | SLC6A4 (0.49) | SLC6A4SLC6A2SLC6A3KMT2AGAA | |
| SCHEMBL5318577 | 0.82 | SLC6A4 (0.46) | ALDH1A1KDM4EHSD17B10SLC6A4SLC6A2 | |
| SCHEMBL1535358 | 0.82 | SLC6A4 (0.46) | ALDH1A1KDM4EHSD17B10SLC6A4SLC6A2 | |
| SCHEMBL11948165 | 0.82 | KDM4E (0.45) | ALDH1A1KDM4EHSD17B10SLC6A4SLC6A2 | |
| SCHEMBL11948170 | 0.82 | KDM4E (0.45) | ALDH1A1KDM4EHSD17B10SLC6A4SLC6A2 | |
| SCHEMBL4438949 | 0.82 | KDM4E (0.39) | ALDH1A1KDM4EHSD17B10SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829731-B2 | Methylhydroxylaminopropanol derivative and its use as intermediate for preparation of 3-methylamino-1-(2-thienyl)propan-1-OL | SCI PHARMTECH, INC. (TW) | 2010-11-09 | — | — | US | claimed |
| US-20090112000-A1 | METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF 3-METHYLAMINO-1-(2-THIENYL)PROPAN-1-OL | SCI PHARMTECH, INC. (TW) | 2009-04-30 | — | — | US | claimed |
| US-8420832-B2 | Optically active methylhydroxylaminopropanol derivative and its use as intermediate for preparation of (S)-(-)-3-methylamino-1-(-2-thienyl)propan-1-ol | SCI PHARMTECH, INC. (TW) | 2013-04-16 | — | — | US | disclosed |
| US-8420832-B2 | Optically active methylhydroxylaminopropanol derivative and its use as intermediate for preparation of (S)-(-)-3-methylamino-1-(-2-thienyl)propan-1-ol | SCI PHARMTECH, INC. (TW) | 2013-04-16 | — | — | US | disclosed |
| US-20120190869-A1 | OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF (S)-(-)-3-METHYLAMINO-1-(-2-THIENYL)PROPAN-1-OL | SCI PHARMTECH, INC. (TW) | 2012-07-26 | — | — | US | disclosed |
| US-20120190869-A1 | OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF (S)-(-)-3-METHYLAMINO-1-(-2-THIENYL)PROPAN-1-OL | SCI PHARMTECH, INC. (TW) | 2012-07-26 | — | — | US | disclosed |
| US-8168805-B2 | Optically active methylhydroxylaminopropanol compound and its use as intermediate for preparation of (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol | SCI PHARMTECH, INC (TW) | 2012-05-01 | — | — | US | disclosed |
| US-8168805-B2 | Optically active methylhydroxylaminopropanol compound and its use as intermediate for preparation of (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol | SCI PHARMTECH, INC (TW) | 2012-05-01 | — | — | US | disclosed |
| US-7829731-B2 | Methylhydroxylaminopropanol derivative and its use as intermediate for preparation of 3-methylamino-1-(2-thienyl)propan-1-OL | SCI PHARMTECH, INC. (TW) | 2010-11-09 | — | — | US | disclosed |
| US-7829731-B2 | Methylhydroxylaminopropanol derivative and its use as intermediate for preparation of 3-methylamino-1-(2-thienyl)propan-1-OL | SCI PHARMTECH, INC. (TW) | 2010-11-09 | — | — | US | disclosed |
| US-20090112000-A1 | METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF 3-METHYLAMINO-1-(2-THIENYL)PROPAN-1-OL | SCI PHARMTECH, INC. (TW) | 2009-04-30 | — | — | US | disclosed |
| US-20090112000-A1 | METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF 3-METHYLAMINO-1-(2-THIENYL)PROPAN-1-OL | SCI PHARMTECH, INC. (TW) | 2009-04-30 | — | — | US | disclosed |
| US-20090112001-A1 | OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF (S)-(-)-3-METHYLAMINO-1-(2-THIENYL)PROPAN-1-OL | SCI PHARMTECH, INC. (TW) | 2009-04-30 | — | — | US | disclosed |
| US-20090112001-A1 | OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF (S)-(-)-3-METHYLAMINO-1-(2-THIENYL)PROPAN-1-OL | SCI PHARMTECH, INC. (TW) | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090112000-A1 | METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF 3-METHYLAMINO-1-(2-THIENYL)PROPAN-1-OL | PNMT, HPD, MSMO1 | SLC6A4 757/4885OPRM1 107/4885ALDH1A1 453/4885 |
| US-20120190869-A1 | OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF (S)-(-)-3-METHYLAMINO-1-(-2-THIENYL)PROPAN-1-OL | THOP1, HPD, PNMT | SLC6A4 751/4885OPRM1 69/4885ALDH1A1 341/4885 |
| US-20090112001-A1 | OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF (S)-(-)-3-METHYLAMINO-1-(2-THIENYL)PROPAN-1-OL | THOP1, HPD, PNMT | SLC6A4 615/4885OPRM1 80/4885ALDH1A1 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.