Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 5/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30746560 | 1.00 | NUDT1 (0.53) | NUDT1TGFBR1CSF1RACVR1BACVRL1 | |
| SCHEMBL30746391 | 0.87 | NUDT1 (0.53) | NUDT1TGFBR1CSF1RCNR2MAP2K1 | |
| SCHEMBL26985321 | 0.87 | NUDT1 (0.53) | NUDT1TGFBR1CSF1RCNR2MAP2K1 | |
| SCHEMBL26984900 | 0.85 | NUDT1 (0.56) | NUDT1TGFBR1CSF1RACVR1BACVRL1 | |
| SCHEMBL30746487 | 0.85 | NUDT1 (0.56) | NUDT1TGFBR1CSF1RACVR1BACVRL1 | |
| SCHEMBL30746686 | 0.76 | NUDT1 (0.43) | NUDT1CSF1REGFRCNR2MAP2K1 | |
| SCHEMBL26985203 | 0.76 | NUDT1 (0.43) | NUDT1CSF1REGFRCNR2MAP2K1 | |
| SCHEMBL30746436 | 0.74 | NUDT1 (0.40) | NUDT1EGFRCNR2FGFR1FLT1 | |
| SCHEMBL26985312 | 0.74 | NUDT1 (0.40) | NUDT1EGFRCNR2FGFR1FLT1 | |
| SCHEMBL15239842 | 0.73 | TGFBR1 (0.45) | NUDT1TGFBR1ABL1ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260001845-A1 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | NESTED THERAPEUTICS INC (US) | 2026-01-01 | — | — | US | disclosed |
| US-20250288571-A1 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | NESTED THERAPEUTICS, INC. | 2025-09-18 | — | — | US | disclosed |
| WO-2024010925-A2 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | NESTED THERAPEUTICS, INC. (US) | 2024-01-11 | — | — | WO | disclosed |
| WO-2024010925-A2 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | NESTED THERAPEUTICS, INC. (US) | 2024-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260001845-A1 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | MAPK6, MAPK3, MAPK1 | NUDT1 1810/4885TGFBR1 1219/4885CSF1R 3256/4885 |
| US-20250288571-A1 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | BRAF, MAP3K1, MAP3K5 | NUDT1 2559/4885TGFBR1 2807/4885CSF1R 1602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.