Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.52 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.52 |
| ▸ | TACR2 | P21452 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CCR8 | P51685 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4878355 | 0.91 | SIGMAR1 (0.60) | SIGMAR1L3MBTL1ALDH1A1CYP2D6TSHR | |
| SCHEMBL4881599 | 0.89 | L3MBTL1 (0.60) | SIGMAR1L3MBTL1ALDH1A1NPFFR1NPFFR2 | |
| SCHEMBL8349894 | 0.87 | SIGMAR1 (0.55) | SIGMAR1L3MBTL1ALDH1A1NPFFR1NPFFR2 | |
| SCHEMBL8349895 | 0.86 | L3MBTL1 (0.54) | SIGMAR1L3MBTL1ALDH1A1NPFFR1NPFFR2 | |
| SCHEMBL4883886 | 0.85 | L3MBTL1 (0.54) | SIGMAR1L3MBTL1ALDH1A1NPFFR1NPFFR2 | |
| SCHEMBL476242 | 0.84 | OPRL1 (0.60) | SIGMAR1ALDH1A1NPFFR1NPFFR2OPRM1 | |
| SCHEMBL2699787 | 0.83 | CHRM2 (0.55) | SIGMAR1ALDH1A1NPFFR1NPFFR2OPRM1 | |
| SCHEMBL4883883 | 0.83 | MMP1 (0.52) | SIGMAR1L3MBTL1ALDH1A1LMNACCR8 | |
| Hydrochloric Acid SCHEMBL2158958 | 0.83 | POLB (0.61) | SIGMAR1ALDH1A1NPFFR1NPFFR2OPRM1 | |
| SCHEMBL4816046 | 0.82 | ALDH1A1 (0.80) | SIGMAR1L3MBTL1ALDH1A1OPRM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2228065-B1 | Heterocyclo inhibitors of potassium channel function | BRISTOL MYERS SQUIBB CO (US) | 2012-12-26 | — | — | EP | disclosed |
| EP-1501467-B1 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2012-05-09 | — | — | EP | disclosed |
| EP-2228065-A2 | Heterocyclo inhibitors of potassium channel function | Bristol-Myers Squibb Company (US) | 2010-09-15 | — | — | EP | disclosed |
| US-20090312307-A1 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY | 2009-12-17 | — | — | US | disclosed |
| US-7582654-B2 | Heterocyclo inhibitors of potassium channel function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-01 | — | — | US | disclosed |
| US-7005436-B2 | Heterocyclo inhibitors of potassium channel function | BRISTOL MYERS SQUIBB COMPANY (US) | 2006-02-28 | — | — | US | disclosed |
| US-20060014792-A1 | Heterocyclo inhibitors of potassium channel function | LLOYD JOHN | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014792-A1 | Heterocyclo inhibitors of potassium channel function | KCNJ2, KCNH2, KCNQ5 | SIGMAR1 2910/4885L3MBTL1 1381/4885ALDH1A1 3941/4885 |
| US-20090312307-A1 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | KCNJ2, KCNH2, KCNQ5 | SIGMAR1 2910/4885L3MBTL1 1381/4885ALDH1A1 3941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.