Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2338480 | 0.98 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL10772899 | 0.90 | SMN1; SMN2 (0.50) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL16823384 | 0.88 | SMN1; SMN2 (0.49) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL3196430 | 0.82 | HTR2C (0.45) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL6764695 | 0.76 | SIGMAR1 (0.45) | ALDH1A1MEN1KMT2ASIGMAR1NOTUM | |
| SCHEMBL5872141 | 0.76 | ALOX15 (0.46) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL27936706 | 0.75 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL8180438 | 0.75 | OPRM1 (0.44) | MAPTKDM4EESR2CHRM1 | |
| SCHEMBL28094982 | 0.75 | HTR1A (0.51) | ALDH1A1SIGMAR1TSHRHPGDKDM4E | |
| SCHEMBL31218824 | 0.73 | CHRM2 (0.39) | ALDH1A1MEN1KMT2AUSP2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230113944-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-04-13 | — | — | US | disclosed |
| EP-4087847-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | The Regents of the University of California (US) | 2022-11-16 | — | — | EP | disclosed |
| US-20180271924-A1 | COMPOUND AND METHOD FOR REDUCING INFLAMMATION, PAIN, ALLERGY, FLU AND COLD SYMPTOMS | KARIMAN ALEXANDER (US) | 2018-09-27 | — | — | US | disclosed |
| CN-106632388-A | Naturally active drug intermediate with high biological activity and preparation method thereof | 胡寅俊 | 2017-05-10 | — | — | CN | disclosed |
| CN-106632388-A | Naturally active drug intermediate with high biological activity and preparation method thereof | 胡寅俊 | 2017-05-10 | — | — | CN | disclosed |
| CN-104274441-B | Application of selaginella tamariscina alkaloid in preparation of medicine for treating thrombotic diseases | 中国药科大学 | 2017-01-11 | — | — | CN | disclosed |
| CN-104274441-A | Application of selaginella tamariscina alkaloid in preparation of medicine for treating thrombotic diseases | UNIV CHINA PHARMA | 2015-01-14 | — | — | CN | disclosed |
| EP-1715863-B1 | ENHANCEMENT OF AMPAKINE-INDUCED FACILITATION OF SYNAPTIC RESPONSES BY CHOLINESTERASE INHIBITORS | CORTEX PHARMA INC (US) | 2012-05-09 | — | — | EP | disclosed |
| EP-1715863-A4 | ENHANCEMENT OF AMPAKINE-INDUCED FACILITATION OF SYNAPTIC RESPONSES BY CHOLINESTERASE INHIBITORS | CORTEX PHARMA INC (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1715863-A2 | ENHANCEMENT OF AMPAKINE-INDUCED FACILITATION OF SYNAPTIC RESPONSES BY CHOLINESTERASE INHIBITORS | CORTEX PHARMACEUTICALS, INC. (US) | 2006-11-02 | — | — | EP | disclosed |
| US-20050228019-A1 | Enhancement of ampakine-Induced facilitation of synaptic responses by cholinesterase inhibitors | CORTEX PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | US | disclosed |
| WO-2005072345-A2 | ENHANCEMENT OF AMPAKINE-INDUCED FACILITATION OF SYNAPTIC RESPONSES BY CHOLINESTERASE INHIBITORS | CORTEX PHARMACEUTICALS INC. (US) | 2005-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230113944-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SMPD2, PSEN2, SMN1; SMN2 | ALDH1A1 2902/4885MEN1 3433/4885KMT2A 1895/4885 |
| US-20050228019-A1 | Enhancement of ampakine-Induced facilitation of synaptic responses by cholinesterase inhibitors | GRIK1, GRIK2, GRIK4 | ALDH1A1 2582/4885MEN1 4505/4885KMT2A 1737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.