Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2704963 | 0.98 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL16823384 | 0.90 | SMN1; SMN2 (0.49) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL10772899 | 0.88 | SMN1; SMN2 (0.50) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL3196430 | 0.81 | HTR2C (0.45) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL6764695 | 0.74 | SIGMAR1 (0.45) | ALDH1A1MEN1KMT2ASIGMAR1SMN1; SMN2 | |
| SCHEMBL5872141 | 0.74 | ALOX15 (0.46) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL27936706 | 0.73 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL8180438 | 0.73 | OPRM1 (0.44) | CHRM1MAPTKDM4EESR2 | |
| SCHEMBL28094982 | 0.73 | HTR1A (0.51) | ALDH1A1SIGMAR1TSHRHPGDKDM4E | |
| SCHEMBL31218824 | 0.72 | CHRM2 (0.39) | ALDH1A1MEN1KMT2AUSP2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114591327-B | Indoline piperidine urea TRPV1 antagonism and MOR agonism double-target-point medicine, preparation method and application | 河南大学 | 2023-02-07 | — | — | CN | claimed |
| CN-114591327-A | Indoline piperidine urea type TRPV1 antagonistic and MOR agonistic double-target-point medicine, preparation method and application | 河南大学 | 2022-06-07 | — | — | CN | claimed |
| US-10155985-B2 | Evaluation of eosinophilic esophagitis | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2018-12-18 | — | — | US | disclosed |
| US-20170067111-A1 | Evaluation of Eosinophilic Esophagitis | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2017-03-09 | — | — | US | disclosed |
| CN-106397116-A | 1-acenaphthenol synthesis and enantiomer separation method | 王际菊 | 2017-02-15 | — | — | CN | disclosed |
| CN-105829311-A | SPIROINDOLINE ANTIPARASITIC DERIVATIVES | 硕腾服务有限责任公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-105308053-A | Spiroindoline derivatives useful as gonadotropin releasing hormone receptor antagonists | Bayer Pharma AG | 2016-02-03 | — | — | CN | disclosed |
| US-8030003-B2 | Diagnosis of eosinophilic esophagitis based on presence of an elevated level of eotaxin-3 | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2011-10-04 | — | — | US | disclosed |
| US-20110195500-A1 | METHODS AND COMPOSITIONS FOR MITIGATING EOSINOPHILIC ESOPHAGITIS BY MODULATING LEVELS AND ACTIVITY OF EOTAXIN-3 | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2011-08-11 | — | — | US | disclosed |
| US-20090269774-A1 | EVALUATION OF EOSINOPHILIC ESOPHAGITIS | CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2009-10-29 | — | — | US | disclosed |
| US-20090233275-A1 | EOTAXIN-3 IN EOSINOPHILIC ESOPHAGITIS | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2009-09-17 | — | — | US | disclosed |
| US-7071201-B2 | Serotonin antagonism; muscle relaxant for myotonia; such as 1-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)-7-methoxy-1,2,3,4 -tetrahydroquinoline | EISAI CO., LTD. (JP) | 2006-07-04 | — | — | US | disclosed |
| CN-1204121-C | 1,4-substituted cyclic amine derivatives | EISAI CO LTD (JP) | 2005-06-01 | — | — | CN | disclosed |
| EP-0976732-B1 | 1,4-SUBSTITUTED CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2004-11-24 | — | — | EP | disclosed |
| US-6579881-B2 | Indoles | EISAI CO., LTD. (JP) | 2003-06-17 | — | — | US | disclosed |
| US-6448243-B1 | SEROTONIN ANTAGONIST FOR TREATING, AMELIORATING AND PREVENTING SPASTIC PARALYSIS OR CENTRAL MUSCLE RELAXANTS FOR AMELIORATING MYOTONIA | EISAI CO., LTD. (JP) | 2002-09-10 | — | — | US | disclosed |
| US-20020086999-A1 | Certain quinoline derivatives | EISAI CO., LTD. | 2002-07-04 | — | — | US | disclosed |
| US-20020019531-A1 | Indoles | EISAI CO., LTD. | 2002-02-14 | — | — | US | disclosed |
| CN-1253547-A | 1,4-substituted cyclic amine derivatives | EISAI CO LTD (JP) | 2000-05-17 | — | — | CN | disclosed |
| EP-0976732-A1 | 1,4-SUBSTITUTED CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-02-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019531-A1 | Indoles | INMT, MUSK, MB | ALDH1A1 3599/4885MEN1 424/4885KMT2A 1128/4885 |
| US-20020086999-A1 | Certain quinoline derivatives | CHRM1, CHRNA5, CHRNA4 | ALDH1A1 3941/4885MEN1 574/4885KMT2A 1347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.