Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 6/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | ADH1C | P00326 | 1/20 | 0.34 |
| ▸ | ADH1A | P07327 | 1/20 | 0.34 |
| ▸ | ADH4 | P08319 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.31 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.30 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602011 | 0.97 | DNM1 (0.48) | DNM1CA12CA1CA2CA9 | |
| SCHEMBL270407 | 0.97 | DNM1 (0.48) | DNM1CA12CA1CA2CA9 | |
| SCHEMBL271649 | 0.97 | DNM1 (0.48) | DNM1CA12CA1CA2CA9 | |
| SCHEMBL269573 | 0.97 | DNM1 (0.42) | DNM1CA12CA1CA2CA9 | |
| SCHEMBL271233 | 0.95 | DNM1 (0.46) | DNM1CA12CA1CA2CA9 | |
| SCHEMBL270747 | 0.95 | DNM1 (0.40) | DNM1CA12CA1CA2CA9 | |
| SCHEMBL269626 | 0.93 | DNM1 (0.44) | DNM1CA12CA1CA2CA9 | |
| SCHEMBL269464 | 0.92 | ALDH1A1 (0.37) | DNM1CA12CA1CA2CA9 | |
| SCHEMBL269999 | 0.90 | DNM1 (0.40) | DNM1CA12CA1CA2CA9 | |
| SCHEMBL271652 | 0.87 | DNM1 (0.44) | DNM1CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 195 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415347-B2 | Substituted tetracyclic tetahydrofuran, pyrrolidine and tetrahydrothiophene derivatives | JANSSEN PHARMACEUTICA, NV (BE) | 2013-04-09 | — | — | US | claimed |
| US-8404729-B2 | Heterocyclic tetracyclic tetrahydrofuran derivatives | JANSSEN PHARMACEUTICA, NV (BE) | 2013-03-26 | — | — | US | claimed |
| US-20120238563-A1 | NOVEL UNSATURATED TETRACYCLIC TETRAHYDROFURAN DERIVATIVES | CID-NUNEZ JOSE MARIA (ES) | 2012-09-20 | — | — | US | claimed |
| US-20120035170-A1 | NOVEL UNSATURATED TETRACYCLIC TETRAHYDROFURAN DERIVATIVES | NUNEZ JOSE MARIA (ES) | 2012-02-09 | — | — | US | claimed |
| JP-4823221-B2 | — | — | 2011-11-24 | — | — | JP | claimed |
| US-8022102-B2 | Unsaturated tetracyclic tetrahydrofuran derivatives | JANSSEN PHARMACEUTICA, NV (BE) | 2011-09-20 | — | — | US | claimed |
| US-20110144094-A1 | HETEROCYCLIC TETRACYCLIC TETRAHYDROFURAN DERIVATIVES | CID-NUNEZ JOSE MARIA | 2011-06-16 | — | — | US | claimed |
| US-7915249-B2 | serotonin 5-HT2A, 5-HT2C and dopamin D2 receptors antagonist, and norepinephrine reuptake inhibitor; antidepressant, anxiolytic agent; psychosis, schizophrenia, bipolar and sexual disorders, obesity | JANSSEN PHARMACEUTICAL NV (BE) | 2011-03-29 | — | — | US | claimed |
| US-20100331325-A1 | NOVEL SUBSTITUTED TETRACYCLIC TETRAHYDROFURAN, PYRROLIDINE AND TETRAHYDROTHIOPHENE DERIVATIVES | CID-NUNEZ JOSE MARIA | 2010-12-30 | — | — | US | claimed |
| US-7799785-B2 | Substituted tetracyclic tetahydrofuran, pyrrolidine and tetrahydrothiophene derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-21 | — | — | US | claimed |
| WO-2006000555-A2 | NOVEL UNSATURATED TETRACYCLIC TETRAHYDROFURAN DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-01-05 | — | — | WO | claimed |
| JP-2002501515-A | — | — | 2002-01-15 | — | — | JP | claimed |
| US-6313344-B1 | PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-11-06 | — | — | US | claimed |
| EP-0984923-A1 | O-BENZYL OXIME ETHERS AND THEIR USE AS PESTICIDES | Novartis AG (CH) | 2000-03-15 | — | — | EP | claimed |
| WO-1998054125-A1 | O-BENZYL OXIME ETHERS AND THEIR USE AS PESTICIDES | NOVARTIS AG (CH) | 1998-12-03 | — | — | WO | claimed |
| EP-0701553-B1 | ARYLPYRAZOLE FUNGICIDES | RHONE POULENC AGROCHIMIE (FR) | 1997-10-01 | — | — | EP | claimed |
| EP-0769905-A1 | FUNGICIDAL COMPOSITIONS CONTAINING 3-PHENYL-PYRAZOLE DERIVATIVES FOR TREATING PROPAGATIVE PLANT STOCK, NOVEL 3-PHENYL-PYRAZOLE DERIVATIVES, AND FUNGICIDAL USES THEREOF | RHONE-POULENC AGROCHIMIE (FR) | 1997-05-02 | — | — | EP | claimed |
| EP-0701553-A1 | ARYLPYRAZOLE FUNGICIDES | RHONE POULENC AGROCHIMIE (FR) | 1996-03-20 | — | — | EP | claimed |
| WO-1996002138-A1 | FUNGICIDAL COMPOSITIONS CONTAINING 3-PHENYL-PYRAZOLE DERIVATIVES FOR TREATING PROPAGATIVE PLANT STOCK, NOVEL 3-PHENYL-PYRAZOLE DERIVATIVES, AND FUNGICIDAL USES THEREOF | RHONE POULENC AGROCHIMIE (FR) | 1996-02-01 | — | — | WO | claimed |
| WO-1994029276-A1 | ARYLPYRAZOLE FUNGICIDES | RHONE POULENC AGROCHIMIE (FR) | 1994-12-22 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035170-A1 | NOVEL UNSATURATED TETRACYCLIC TETRAHYDROFURAN DERIVATIVES | HTR2C, HTR2A, HTR1A | DNM1 2115/4885CA12 4669/4885CA1 4149/4885 |
| US-20100331325-A1 | NOVEL SUBSTITUTED TETRACYCLIC TETRAHYDROFURAN, PYRROLIDINE AND TETRAHYDROTHIOPHENE DERIVATIVES | HTR2C, TPH2, HTR2A | DNM1 1693/4885CA12 4625/4885CA1 3970/4885 |
| US-20110144094-A1 | HETEROCYCLIC TETRACYCLIC TETRAHYDROFURAN DERIVATIVES | HTR2C, HTR2A, HTR5A | DNM1 1560/4885CA12 4409/4885CA1 3599/4885 |
| US-20120238563-A1 | NOVEL UNSATURATED TETRACYCLIC TETRAHYDROFURAN DERIVATIVES | HTR2C, HTR2A, HTR1A | DNM1 2115/4885CA12 4669/4885CA1 4149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.