SCHEMBL27083155

SCHEMBL27083155

COc1nc(-c2cnco2)nc(F)c1C(F)(F)F

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 4/20 0.33
IMPDH1 P20839 1/20 0.33
CYP11B1 P15538 1/20 0.31
CYP11B2 P19099 1/20 0.31
AAK1 Q2M2I8 1/20 0.31
LMNA P02545 1/20 0.31
PKM P14618 1/20 0.31
LATS1 O95835 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30637695 1.00 IMPDH2 (0.33) IMPDH2IMPDH1CYP11B1CYP11B2AAK1
SCHEMBL29675203 0.78 RAB9A (0.42) LMNAPKM
SCHEMBL23324992 0.78 RAB9A (0.42) LMNAPKM
SCHEMBL27083154 0.76 NOTUM (0.43) LMNA
SCHEMBL27083198 0.76 RAB9A (0.34)
SCHEMBL30637693 0.76 RAB9A (0.34)
SCHEMBL29635359 0.75 CYP1A1 (0.32) CYP11B1CYP11B2
SCHEMBL22042745 0.75 CYP1A1 (0.32) CYP11B1CYP11B2
SCHEMBL23324042 0.75 ADORA2A (0.35)
SCHEMBL23302331 0.74 RORC (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12583847-B2 Fluorinated pyrimidine compound and method for producing same UNIMATEC CO., LTD. (JP) 2026-03-24 US disclosed
US-20240190853-A1 FLUORINATED PYRIMIDINE COMPOUND AND METHOD FOR PRODUCING SAME UNIMATEC CO., LTD. (JP) 2024-06-13 US disclosed
EP-4317154-A1 FLUORINATED PYRIMIDINE COMPOUND AND METHOD FOR PRODUCING SAME Unimatec Co., Ltd. (JP) 2024-02-07 EP disclosed
CN-117043158-A Fluorine-containing pyrimidine compound and process for producing the same 优迈特株式会社 2023-11-10 CN disclosed
WO-2022202537-A1 FLUORINATED PYRIMIDINE COMPOUND AND METHOD FOR PRODUCING SAME ユニマテック株式会社 2022-09-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240190853-A1 FLUORINATED PYRIMIDINE COMPOUND AND METHOD FOR PRODUCING SAME POF1B, CCNA1, AOC2 IMPDH2 760/4885IMPDH1 403/4885CYP11B1 310/4885
US-12583847-B2 Fluorinated pyrimidine compound and method for producing same NAF1, CCNA1, HAO1 IMPDH2 1642/4885IMPDH1 618/4885CYP11B1 111/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.