SCHEMBL27123389

SCHEMBL27123389

CNCCCC1CCC2(CC1)CCN(C(=O)c1ccc(Cl)c(N3CCC(=O)NC3=O)c1)CC2

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ FFAR4 Q5NUL3 8/20 0.38
▸ SOS1 Q07889 2/20 0.37
▸ SMYD3 Q9H7B4 5/20 0.36
▸ TNKS O95271 1/20 0.35
▸ PARP1 P09874 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ DRD3 P35462 1/20 0.35
▸ HTR1A P08908 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30014467 1.00 FFAR4 (0.38) FFAR4SOS1SMYD3TNKSPARP1
SCHEMBL27123175 0.92 HTR1A (0.39) TNKSPARP1HTR1A
SCHEMBL30864049 0.90 FFAR4 (0.40) FFAR4SOS1KMT2ADRD3
SCHEMBL29892407 0.89 DDB1 (0.40) FFAR4SOS1SMYD3TNKSPARP1
SCHEMBL30267237 0.89 LIPG (0.40) SMYD3TNKSPARP1HTR1A
SCHEMBL27118484 0.88 FFAR4 (0.45) FFAR4SOS1KMT2ADRD3
SCHEMBL29893498 0.88 FFAR4 (0.45) FFAR4SOS1KMT2ADRD3
SCHEMBL30864092 0.87 FFAR4 (0.39) FFAR4SOS1DRD3
SCHEMBL30864018 0.85 FFAR4 (0.41) FFAR4SOS1DRD3
SCHEMBL25920200 0.85 MGLL (0.38) FFAR4TNKSPARP1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240261418-A1 SOS1 DEGRADING AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF LEADINGTAC PHARMACEUTICAL (SHAOXING) CO., LTD. (CN) 2024-08-08 — — US disclosed
EP-4328219-A1 SOS1 DEGRADING AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Shanghai Leadingtac Pharmaceutical Co. Ltd. (CN) 2024-02-28 — — EP disclosed
EP-4328219-A1 SOS1 DEGRADING AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Shanghai Leadingtac Pharmaceutical Co. Ltd. (CN) 2024-02-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240261418-A1 SOS1 DEGRADING AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SOS1, RAC1, RSU1 FFAR4 3977/4885SOS1 1/4885SMYD3 4063/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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