Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13256277 | 0.83 | HDAC4 (0.48) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL19941820 | 0.82 | BTK (0.46) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL8245338 | 0.81 | TSHR (0.54) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL8245341 | 0.81 | TSHR (0.54) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL4730477 | 0.81 | ITGB3 (0.48) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL2485232 | 0.79 | CTSS (0.45) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL12767866 | 0.79 | CTSK (0.52) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL9358337 | 0.79 | KMT2A (0.49) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL9358329 | 0.79 | KMT2A (0.49) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL13048263 | 0.79 | HDAC4 (0.65) | CTSKCTSSHDAC4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |