Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825789 | 0.87 | SLC1A2 (0.49) | KMT2AMAPTHPGDSMN1; SMN2RAB9A | |
| SCHEMBL3146539 | 0.86 | CTSS (0.43) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL4177126 | 0.83 | MDM2 (0.44) | MDM2TDP1L3MBTL1KMT2ACES1 | |
| SCHEMBL3316473 | 0.83 | MDM2 (0.44) | MDM2TDP1L3MBTL1KMT2ACES1 | |
| SCHEMBL4332252 | 0.81 | LMNA (0.47) | MDM2TDP1L3MBTL1KMT2ACES1 | |
| SCHEMBL4327115 | 0.79 | NPC1 (0.49) | TDP1MAPTMAPK1SMN1; SMN2LMNA | |
| SCHEMBL927300 | 0.77 | MMP1 (0.47) | MDM2TDP1L3MBTL1KMT2ACES1 | |
| SCHEMBL21273531 | 0.75 | HPGDS (0.47) | TDP1L3MBTL1MAPTKDM4EHPGD | |
| SCHEMBL16101837 | 0.75 | CYP3A4 (0.39) | MDM2TDP1L3MBTL1KMT2ACES1 | |
| SCHEMBL11215012 | 0.75 | TDP1 (0.47) | MDM2TDP1L3MBTL1KMT2ACES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |