Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.61 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL272063 | 0.85 | GABRA1 (0.69) | TRPA1GABRA1GABRG2GABRB3MEN1 | |
| SCHEMBL8163756 | 0.81 | GABRA1 (0.47) | TRPA1GABRA1GABRG2GABRB3KDM4E | |
| SCHEMBL8274638 | 0.79 | GABRA1 (0.45) | TRPA1GABRA1GABRG2GABRB3MEN1 | |
| SCHEMBL15286750 | 0.78 | MEN1 (0.55) | TRPA1GABRA1GABRG2GABRB3MEN1 | |
| SCHEMBL9876993 | 0.76 | MAPT (0.68) | TRPA1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL436060 | 0.76 | TRPA1 (1.00) | TRPA1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL29404696 | 0.76 | TRPA1 (1.00) | TRPA1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL1929502 | 0.74 | KMT2A (0.54) | TRPA1GABRA1GABRG2GABRB3MEN1 | |
| SCHEMBL10779476 | 0.72 | TRPA1 (0.59) | TRPA1GABRA1GABRG2GABRB3MEN1 | |
| SCHEMBL3246487 | 0.72 | APP (0.63) | TRPA1MEN1KMT2AMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133898-B2 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-13 | — | — | US | disclosed |
| US-8133898-B2 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-13 | — | — | US | disclosed |
| US-8133898-B2 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-13 | — | — | US | disclosed |
| US-7825242-B2 | Dipeptidyl peptidase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMTED (JP) | 2010-11-02 | — | — | US | disclosed |
| US-7825242-B2 | Dipeptidyl peptidase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMTED (JP) | 2010-11-02 | — | — | US | disclosed |
| US-7825242-B2 | Dipeptidyl peptidase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMTED (JP) | 2010-11-02 | — | — | US | disclosed |
| US-20100137310-A1 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-03 | — | — | US | disclosed |
| US-20100137310-A1 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-03 | — | — | US | disclosed |
| US-20100137310-A1 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-03 | — | — | US | disclosed |
| WO-2008121506-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-10-09 | — | — | WO | disclosed |
| EP-1773832-A2 | DIPEPTIDYL PEPTIDASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006019965-A2 | DIPEPTIDYL PEPTIDASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-02-23 | — | — | WO | disclosed |
| WO-2006020017-A2 | DIPEPTIDYL PEPTIDASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-02-23 | — | — | WO | disclosed |
| US-20060014764-A1 | Dipeptidyl peptidase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014764-A1 | Dipeptidyl peptidase inhibitors | DPP3, DPP4, DPP7 | TRPA1 4053/4885GABRA1 3540/4885GABRG2 2931/4885 |
| US-20100137310-A1 | RENIN INHIBITORS | REN, ACE, PRSS3 | TRPA1 3538/4885GABRA1 4000/4885GABRG2 4090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.