SCHEMBL2717321

SCHEMBL2717321

CCc1ccc(CN(C(=O)COc2ccc(C)cc2)c2ccccc2)s1

nearest known ligand 0.70

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 15/20 0.70
▸ GAA P10253 1/20 0.53
▸ SMN1; SMN2 Q16637 1/20 0.53
▸ MEN1 O00255 1/20 0.52
▸ KMT2A Q03164 1/20 0.52
▸ TP53 P04637 2/20 0.52
▸ LMNA P02545 1/20 0.50
▸ TDP1 Q9NUW8 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2717345 0.89 TRPM8 (0.71) TRPM8GAASMN1; SMN2MEN1KMT2A
SCHEMBL2717047 0.82 TRPM8 (1.00) TRPM8TP53
SCHEMBL2719444 0.81 SMN1; SMN2 (0.71) TRPM8GAASMN1; SMN2MEN1KMT2A
SCHEMBL17230201 0.80 TRPM8 (0.64) TRPM8GAASMN1; SMN2MEN1KMT2A
SCHEMBL2720389 0.77 TRPM8 (0.70) TRPM8GAASMN1; SMN2TP53
SCHEMBL2720161 0.77 TRPM8 (0.70) TRPM8GAASMN1; SMN2MEN1KMT2A
SCHEMBL6831040 0.77 ALDH1A1 (0.47) GAASMN1; SMN2MEN1KMT2ATP53
SCHEMBL2717555 0.76 GAA (0.67) TRPM8GAASMN1; SMN2MEN1KMT2A
SCHEMBL2717200 0.76 LMNA (0.82) TRPM8TP53LMNATDP1
SCHEMBL20777298 0.74 TRPM8 (0.60) TRPM8GAASMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025132323-A1 COMPOSITIONS COMPRISING A SUNSCREEN ACTIVE AGENT DSM-FIRMENICH AG (CH) 2025-06-26 — — WO disclosed
CN-118697922-A Perfume dispersing device 弗门尼舍有限公司 2024-09-27 — — CN disclosed
EP-3470407-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED (US) 2024-01-24 — — EP disclosed
CN-109414048-B Coated yeast formulation 弗门尼舍有限公司 2023-09-01 — — CN disclosed
US-11234450-B2 Preparations having a cooling effect SYMRISE AG (DE) 2022-02-01 — — US disclosed
US-11234450-B2 Preparations having a cooling effect SYMRISE AG (DE) 2022-02-01 — — US disclosed
EP-3478089-B1 PLATED YEAST FORMULATIONS FIRMENICH & CIE (CH) 2021-11-03 — — EP disclosed
US-11160894-B2 Perfume emanating device FIRMENICH SA (CH) 2021-11-02 — — US disclosed
CN-108853105-B Cosmetic composition, pharmaceutical composition and food composition 西姆莱斯股份公司 2021-10-15 — — CN disclosed
US-11091734-B2 Plated yeast formulations FIRMENICH SA (CH) 2021-08-17 — — US disclosed
US-20150313820-A1 PREPARATIONS SYMRISE AG (DE) 2015-11-05 — — US disclosed
US-20150313820-A1 PREPARATIONS SYMRISE AG (DE) 2015-11-05 — — US disclosed
EP-2931225-A1 PREPARATIONS Symrise AG (DE) 2015-10-21 — — EP disclosed
WO-2014090293-A1 PREPARATIONS SYMRISE AG (DE) 2014-06-19 — — WO disclosed
US-20130324557-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2013-12-05 — — US disclosed
EP-2635572-A2 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 Senomyx, Inc. (US) 2013-09-11 — — EP disclosed
WO-2012061698-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2012-09-13 — — WO disclosed
WO-2012061698-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2012-09-13 — — WO disclosed
WO-2012061698-A2 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2012-05-10 — — WO disclosed
WO-2012061698-A2 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2012-05-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11160894-B2 Perfume emanating device DPM1, SURF4, FAAH2 TRPM8 151/4885GAA 4602/4885SMN1; SMN2 4203/4885
US-11234450-B2 Preparations having a cooling effect CRAT, CPT2, CPT1A TRPM8 60/4885GAA 1067/4885SMN1; SMN2 528/4885
US-20130324557-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885GAA 3113/4885SMN1; SMN2 2789/4885
US-20150313820-A1 PREPARATIONS CRAT, ACAT2, TAS2R50 TRPM8 101/4885GAA 1009/4885SMN1; SMN2 1059/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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