Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 4/20 | 0.38 |
| ▸ | CES1 | P23141 | 4/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL271819 | 0.92 | TSHR (0.50) | TSHRDAONAPRTCES2CES1 | |
| SCHEMBL201294 | 0.83 | CHRM1 (0.34) | HTR2AHRH1ALDH1A1LMNA | |
| SCHEMBL393486 | 0.83 | CHRM1 (0.34) | HTR2AHRH1ALDH1A1LMNA | |
| Benzoic Acid SCHEMBL11697355 | 0.80 | LMNA (0.39) | TSHRDAONAPRTCES2CES1 | |
| Octadecanoic Acid Amide SCHEMBL8002945 | 0.79 | CES2 (0.48) | TSHRCES2CES1ALDH1A1KMT2A | |
| Benzoic Acid SCHEMBL28737090 | 0.79 | TSHR (0.54) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL1784685 | 0.78 | TSHR (0.45) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL2729573 | 0.78 | TSHR (0.70) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL1786441 | 0.77 | DAO (0.44) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL4837242 | 0.76 | DAO (0.47) | TSHRDAONAPRTCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10442951-B2 | Water dispersible, self-crosslinkable prepolymer composition | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2019-10-15 | — | — | US | disclosed |
| EP-2235077-B2 | USE OF A WATERBORNE COMPOSITION AS A WATERBORNE COATING WITH IMPROVED EARLY WATER BLUSHING AND CHEMICAL RESISTANCE | LUBRIZOL ADVANCED MAT INC (US) | 2017-06-21 | — | — | EP | disclosed |
| US-20170145245-A1 | WATER DISPERSIBLE, SELF-CROSSLINKABLE PREPOLYMER COMPOSITION | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2017-05-25 | — | — | US | disclosed |
| US-9567311-B2 | Water dispersible, self-crosslinkable prepolymer composition | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2017-02-14 | — | — | US | disclosed |
| EP-2807207-B1 | WATER DISPERSIBLE, SELF-CROSSLINKABLE PREPOLYMER COMPOSITION | LUBRIZOL ADVANCED MAT INC (US) | 2016-12-28 | — | — | EP | disclosed |
| WO-2016153818-A1 | BLENDS OF WATER DISPERSIBLE POLYMER WITH DISPERSIONS OF POLYMERS FROM EPOXIDIZED TRIGLYCERIDES | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2016-09-29 | — | — | WO | disclosed |
| US-20140378607-A1 | WATER DISPERSIBLE, SELF-CROSSLINKABLE PREPOLYMER COMPOSITON | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2014-12-25 | — | — | US | disclosed |
| EP-2235077-B1 | WATERBORNE COATINGS WITH IMPROVED EARLY WATER BLUSHING AND CHEMICAL RESISTANCE | LUBRIZOL ADVANCED MAT INC (US) | 2014-03-19 | — | — | EP | disclosed |
| US-8133961-B2 | Waterborne coatings with improved early water blushing and chemical resistance | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2012-03-13 | — | — | US | disclosed |
| EP-2235077-A2 | WATERBORNE COATINGS WITH IMPROVED EARLY WATER BLUSHING AND CHEMICAL RESISTANCE | Lubrizol Advanced Materials, Inc. (US) | 2010-10-06 | — | — | EP | disclosed |
| EP-0501272-A1 | Latex for coatings having improved flexibility | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1992-09-02 | — | — | EP | disclosed |
| US-5122566-A | Free radical emulsion polymerization of monomer mixture, neutralizaton with ammonia | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1992-06-16 | — | — | US | disclosed |
| EP-0476528-A2 | Process for producing stable latex | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1992-03-25 | — | — | EP | disclosed |
| EP-0421909-A2 | Latex for coatings having reduced blushing characteristics | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |
| US-4968741-A | PROTECTIVE COATINGS FOR METALS | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1990-11-06 | — | — | US | disclosed |
| US-4189561-A | FREE RADICAL EMULSION POLYMERIZED; HYDROPHOBIC AND HYDROPHILIC MONOMERS | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1980-02-19 | — | — | US | disclosed |
| US-4153592-A | HYDROPHOBIC-HYDROPHILIC ADDITION INTERPOLYMER, AMINE | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1979-05-08 | — | — | US | disclosed |
| US-4124555-A | FILM FORMING | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1978-11-07 | — | — | US | disclosed |
| US-4097440-A | PAINTS, ADDITION POLYMERS, PLASTICIZERS | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1978-06-27 | — | — | US | disclosed |
| US-4064092-A | ADDITION POLYMER | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1977-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378607-A1 | WATER DISPERSIBLE, SELF-CROSSLINKABLE PREPOLYMER COMPOSITON | COASY, ABHD6, HACL2 | TSHR 4798/4885DAO 462/4885NAPRT 3922/4885 |
| US-10442951-B2 | Water dispersible, self-crosslinkable prepolymer composition | ABHD6, COASY, HACL2 | TSHR 4853/4885DAO 214/4885NAPRT 3767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.