Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27199665 | 0.99 | BRD4 (0.31) | BRD4CREBBPTP53 | |
| Hydrochloric Acid SCHEMBL27199724 | 0.80 | TRPV1 (0.31) | — | |
| SCHEMBL4873780 | 0.80 | LMNA (0.33) | BRD4CREBBPTP53 | |
| SCHEMBL27199727 | 0.79 | — | — | |
| SCHEMBL5608036 | 0.79 | ALDH1A1 (0.34) | BRD4CREBBP | |
| SCHEMBL30915810 | 0.78 | — | — | |
| SCHEMBL1455223 | 0.78 | NPC1 (0.36) | BRD4CREBBPTP53 | |
| SCHEMBL2388282 | 0.76 | NPC1 (0.35) | BRD4CREBBPTP53 | |
| SCHEMBL29669907 | 0.74 | NPC1 (0.32) | BRD4CREBBPTP53 | |
| SCHEMBL16393539 | 0.73 | PDK2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240124618-A1 | Asymmetric Constrained Geometry Catalysts | EXXONMOBIL CHEMICAL PATENTS INC (US) | 2024-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124618-A1 | Asymmetric Constrained Geometry Catalysts | GNE, ESR1, PGR | BRD4 3088/4885CREBBP 1216/4885TP53 1446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.