SCHEMBL2720459

SCHEMBL2720459

CCN(Cc1cccs1)C(=O)c1cc2ccccc2o1

nearest known ligand 0.79

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TRPM8 Q7Z2W7 7/20 0.79
ALDH1A1 P00352 4/20 0.62
NPSR1 Q6W5P4 2/20 0.62
TSHR P16473 2/20 0.56
GAA P10253 1/20 0.56
PKM P14618 1/20 0.56
HPGD P15428 1/20 0.53
NPC1 O15118 2/20 0.53
HTT P42858 1/20 0.53
MAPK1 P28482 2/20 0.52
MAPT P10636 2/20 0.52
ALOX15 P16050 1/20 0.52
RAB9A P51151 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
KMT2A Q03164 3/20 0.50
MEN1 O00255 2/20 0.50
PSMB5 P28074 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2718288 0.88 TRPM8 (1.00) TRPM8ALDH1A1NPSR1TSHRMAPK1
SCHEMBL20902965 0.87 TRPM8 (0.81) TRPM8ALDH1A1NPSR1
SCHEMBL2720862 0.84 TRPM8 (1.00) TRPM8TSHRMAPTKMT2AMEN1
SCHEMBL3724437 0.84 ALDH1A1 (0.62) TRPM8ALDH1A1TSHRHPGDNPC1
SCHEMBL18997978 0.82 TRPM8 (0.60) TRPM8ALDH1A1NPSR1TSHRGAA
SCHEMBL2718406 0.81 TSHR (0.56) TRPM8ALDH1A1NPSR1TSHRGAA
SCHEMBL28226957 0.72 TRPM8 (0.59) TRPM8ALDH1A1
SCHEMBL30524275 0.72 TSHR (1.00) ALDH1A1NPSR1TSHRGAAPKM
SCHEMBL5160471 0.71 TAS1R3 (0.53) ALDH1A1TSHRPKMHPGDNPC1
SCHEMBL22325320 0.71 ALDH1A1 (0.68) ALDH1A1TSHRPKMHPGDNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025132323-A1 COMPOSITIONS COMPRISING A SUNSCREEN ACTIVE AGENT DSM-FIRMENICH AG (CH) 2025-06-26 WO disclosed
CN-118697922-A Perfume dispersing device 弗门尼舍有限公司 2024-09-27 CN disclosed
EP-3470407-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED (US) 2024-01-24 EP disclosed
CN-109414048-B Coated yeast formulation 弗门尼舍有限公司 2023-09-01 CN disclosed
EP-3478089-B1 PLATED YEAST FORMULATIONS FIRMENICH & CIE (CH) 2021-11-03 EP disclosed
US-11160894-B2 Perfume emanating device FIRMENICH SA (CH) 2021-11-02 US disclosed
US-11091734-B2 Plated yeast formulations FIRMENICH SA (CH) 2021-08-17 US disclosed
US-10953007-B2 Compounds useful as modulators of TRPM8 FIRMENICH INCORPORATED (US) 2021-03-23 US disclosed
US-10953007-B2 Compounds useful as modulators of TRPM8 FIRMENICH INCORPORATED (US) 2021-03-23 US disclosed
EP-3478089-A1 PLATED YEAST FORMULATIONS Firmenich SA (CH) 2019-05-08 EP disclosed
US-20160317532-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED 2016-11-03 US disclosed
US-9394287-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2016-07-19 US disclosed
US-9394287-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2016-07-19 US disclosed
US-9394287-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2016-07-19 US disclosed
US-20150313820-A1 PREPARATIONS SYMRISE AG (DE) 2015-11-05 US disclosed
US-20130324557-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2013-12-05 US disclosed
EP-2635572-A2 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 Senomyx, Inc. (US) 2013-09-11 EP disclosed
CN-103201279-A Compounds useful as modulators of TRPM8 SENOMYX INC 2013-07-10 CN disclosed
WO-2012061698-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2012-09-13 WO disclosed
WO-2012061698-A2 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2012-05-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11160894-B2 Perfume emanating device DPM1, SURF4, FAAH2 TRPM8 151/4885ALDH1A1 646/4885NPSR1 374/4885
US-10953007-B2 Compounds useful as modulators of TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885ALDH1A1 1409/4885NPSR1 241/4885
US-20160317532-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885ALDH1A1 1409/4885NPSR1 241/4885
US-20130324557-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885ALDH1A1 1409/4885NPSR1 241/4885
US-20150313820-A1 PREPARATIONS CRAT, ACAT2, TAS2R50 TRPM8 101/4885ALDH1A1 563/4885NPSR1 817/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.