SCHEMBL27238568

SCHEMBL27238568

O=C(N1CCN(C2(c3ccccc3)COC2)CC1)C(F)(F)F.O=S(=O)(Cl)Cl

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 1/20 0.36
▸ KDM1A O60341 1/20 0.36
▸ CTSS P25774 1/20 0.35
▸ CYP2C19 P33261 1/20 0.34
▸ EPHX2 P34913 1/20 0.34
▸ CXCR3 P49682 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ RIPK1 Q13546 1/20 0.33
▸ CNR1 P21554 2/20 0.33
▸ CHRM1 P11229 2/20 0.33
▸ CHRM4 P08173 1/20 0.33
▸ CHRM5 P08912 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27238569 0.89 GRIN2D (0.41) MAPK1KDM1ACTSSCXCR3ALDH1A1
SCHEMBL24762229 0.87 RORC (0.33) CTSSCYP2C19EPHX2
SCHEMBL24763407 0.81 AKR1C3 (0.36) MAPK1KDM1A
SCHEMBL24763409 0.81 AKR1C3 (0.36) CYP2C19ALDH1A1LMNAKMT2ASMN1; SMN2
SCHEMBL24763412 0.79 LMNA (0.39) MAPK1ALDH1A1LMNAKMT2ASMN1; SMN2
SCHEMBL24762716 0.75 RORC (0.34) CTSS
SCHEMBL24762030 0.71 CA1 (0.35) CTSSALDH1A1KMT2ASMN1; SMN2
SCHEMBL30364193 0.69 SIGMAR1 (0.58) —
SCHEMBL24762049 0.69 CXCR3 (0.40) MAPK1EPHX2CXCR3
SCHEMBL24762050 0.68 LMNA (0.41) ALDH1A1LMNAKMT2ASMN1; SMN2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240190821-A1 SULFONAMIDE SUBSTITUTED N-(1H-INDOL-7-YL)BENZENESULFONAMIDES AND USES THEREOF TRIANA BIOMEDICINES INC (US) 2024-06-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240190821-A1 SULFONAMIDE SUBSTITUTED N-(1H-INDOL-7-YL)BENZENESULFONAMIDES AND USES THEREOF PACSIN2, TPX2, PRSS12 MAPK1 4005/4885KDM1A 4539/4885CTSS 2144/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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