Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 10/20 | 0.44 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.44 |
| ▸ | TLK2 | Q86UE8 | 5/20 | 0.44 |
| ▸ | RET | P07949 | 4/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2724238 | 1.00 | PDPK1 (0.44) | PDPK1KDRPDGFRBTLK2RET | |
| SCHEMBL10095156 | 0.70 | PDPK1 (0.63) | PDPK1KDRPDGFRBTLK2RET | |
| SCHEMBL10141206 | 0.67 | — | — | |
| SCHEMBL19596 | 0.67 | — | — | |
| SCHEMBL10141196 | 0.67 | — | — | |
| SCHEMBL30027844 | 0.66 | ALDH1A1 (0.49) | PDPK1KDRPDGFRBTLK2RET | |
| Bromide SCHEMBL17747828 | 0.65 | — | — | |
| SCHEMBL14036942 | 0.65 | ALDH1A1 (0.43) | PDPK1KDRPDGFRBTLK2RET | |
| SCHEMBL4038516 | 0.64 | PDPK1 (0.59) | PDPK1KDRPDGFRBTLK2RET | |
| SCHEMBL9631218 | 0.64 | ALDH1A1 (0.43) | PDPK1KDRPDGFRBTLK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635568-B1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM (KUNSHAN) BIOCHEMICAL TECH CO LTD (CN) | 2017-08-16 | — | — | EP | claimed |
| US-8846953-B2 | Processes for the preparation of 3-(pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles | SCINOPHARM TAIWAN, LTD. (TW) | 2014-09-30 | — | — | US | claimed |
| EP-2635568-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | Scinopharm (Kunshan) Biochemical Technology Co., Ltd. (CN) | 2013-09-11 | — | — | EP | claimed |
| US-20130190512-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM TAIWAN, LTD. (TW) | 2013-07-25 | — | — | US | claimed |
| WO-2012058780-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM (KUNSHAN) BIOCHEMICAL TECHNOLOGY CO., LTD. (CN) | 2012-05-10 | — | — | WO | claimed |
| EP-2635568-B1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM (KUNSHAN) BIOCHEMICAL TECH CO LTD (CN) | 2017-08-16 | — | — | EP | disclosed |
| EP-2635568-B1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM (KUNSHAN) BIOCHEMICAL TECH CO LTD (CN) | 2017-08-16 | — | — | EP | disclosed |
| US-8846953-B2 | Processes for the preparation of 3-(pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles | SCINOPHARM TAIWAN, LTD. (TW) | 2014-09-30 | — | — | US | disclosed |
| US-8846953-B2 | Processes for the preparation of 3-(pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles | SCINOPHARM TAIWAN, LTD. (TW) | 2014-09-30 | — | — | US | disclosed |
| EP-2635568-A4 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM KUNSHAN BIOCHEMICAL TECHNOLOGY CO LTD (CN) | 2014-04-23 | — | — | EP | disclosed |
| JP-2013540779-A | — | — | 2013-11-07 | — | — | JP | disclosed |
| EP-2635568-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | Scinopharm (Kunshan) Biochemical Technology Co., Ltd. (CN) | 2013-09-11 | — | — | EP | disclosed |
| EP-2635568-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | Scinopharm (Kunshan) Biochemical Technology Co., Ltd. (CN) | 2013-09-11 | — | — | EP | disclosed |
| EP-2635568-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | Scinopharm (Kunshan) Biochemical Technology Co., Ltd. (CN) | 2013-09-11 | — | — | EP | disclosed |
| US-20130190512-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM TAIWAN, LTD. (TW) | 2013-07-25 | — | — | US | disclosed |
| US-20130190512-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM TAIWAN, LTD. (TW) | 2013-07-25 | — | — | US | disclosed |
| WO-2012058780-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM (KUNSHAN) BIOCHEMICAL TECHNOLOGY CO., LTD. (CN) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012058780-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM (KUNSHAN) BIOCHEMICAL TECHNOLOGY CO., LTD. (CN) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012058780-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM (KUNSHAN) BIOCHEMICAL TECHNOLOGY CO., LTD. (CN) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190512-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SKP2, SDHA, MDH2 | PDPK1 628/4885KDR 15/4885PDGFRB 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.