SCHEMBL2725876

SCHEMBL2725876

O=C(O)C(C(=O)O)=C1SC=CS1

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADRA1A P35348 1/20 0.46
PDE4D Q08499 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9745480 0.97 ADRA1A (0.45) ADRA1APDE4D
SCHEMBL9745261 0.97 ADRA1A (0.45) ADRA1APDE4D
Water SCHEMBL9745436 0.95 ADRA1A (0.43) ADRA1APDE4D
SCHEMBL8385459 0.79 ADRA1A (0.50) ADRA1APDE4D
SCHEMBL9675143 0.78 ADRA1A (0.44) ADRA1APDE4D
SCHEMBL8055886 0.75 ADRA1A (0.82) ADRA1APDE4D
SCHEMBL9706743 0.73 PTPN1 (0.46)
SCHEMBL9745475 0.72 ADRA1A (0.43) ADRA1APDE4D
Water SCHEMBL9745425 0.70 ADRA1A (0.42) ADRA1APDE4D
SCHEMBL11910041 0.69 ADRA1A (0.61) ADRA1APDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0238726-B1 1,3-DITHIO-2-YLIDENE MALONATES FOR CURING FAT NECROSIS NIHON NOHYAKU CO., LTD. (JP) 1992-09-02 EP claimed
EP-0103206-B1 FEED COMPOSITION NIHON NOHYAKU CO., LTD. (JP) 1986-11-26 EP claimed
EP-0062118-B1 PROCESS FOR PRODUCING 1,3-DITHIOL-2-YLIDENE MALONATES NIHON NOHYAKU CO., LTD. (JP) 1986-07-09 EP claimed
EP-0062119-B1 PROCESS OF PRODUCING 1,3-DITHIOL-2-YLIDENE MALONIC ACID DIALKYL ESTERS NIHON NOHYAKU CO., LTD. (JP) 1986-01-02 EP claimed
EP-0062118-A1 Process for producing 1,3-dithiol-2-ylidene malonates NIHON NOHYAKU CO., LTD. (JP) 1982-10-13 EP claimed
EP-0062119-A1 Process of producing 1,3-dithiol-2-ylidene malonic acid dialkyl esters NIHON NOHYAKU CO., LTD. (JP) 1982-10-13 EP claimed
US-4329479-A FROM 1,1-DIHALDETHYLENE REACTED WITH A DIALKYLCARBONYLKETENE DIMERCAPTIDE NIHON NOHYAKU CO., LTD. (JP) 1982-05-11 US claimed
US-4327223-A USING A TRIHALOGENOETHANE NIHON NOHYAKU CO., LTD. (JP) 1982-04-27 US claimed
JP-52083751-A None JP disclosed
US-10611861-B2 Multifunctional monomers, methods for making multifunctional monomers, polymerizable compositions and products formed thereform NIPPON SHOKUBAI CO., LTD. (JP) 2020-04-07 US disclosed
US-10604601-B2 Multifunctional monomers, methods for making multifunctional monomers, polymerizable compositions and products formed therefrom SIRRUS, INC. (US) 2020-03-31 US disclosed
EP-3517523-A1 MULTIFUNCTIONAL MONOMERS AND METHODS FOR MAKING THEM Sirrus, Inc. (US) 2019-07-31 EP disclosed
US-20180346615-A1 MULTIFUNCTIONAL MONOMERS, METHODS FOR MAKING MULTIFUNCTIONAL MONOMERS, POLYMERIZABLE COMPOSITIONS AND PRODUCTS FORMED THEREFORM NIPPON SHOKUBAI CO., LTD. (JP) 2018-12-06 US disclosed
EP-2768917-B1 MULTIFUNCTIONAL MONOMERS AND METHODS FOR MAKING THEM SIRRUS INC (US) 2018-12-05 EP disclosed
US-4329479-A FROM 1,1-DIHALDETHYLENE REACTED WITH A DIALKYLCARBONYLKETENE DIMERCAPTIDE NIHON NOHYAKU CO., LTD. (JP) 1982-05-11 US disclosed
US-4329479-A FROM 1,1-DIHALDETHYLENE REACTED WITH A DIALKYLCARBONYLKETENE DIMERCAPTIDE NIHON NOHYAKU CO., LTD. (JP) 1982-05-11 US disclosed
US-4327223-A USING A TRIHALOGENOETHANE NIHON NOHYAKU CO., LTD. (JP) 1982-04-27 US disclosed
US-4327223-A USING A TRIHALOGENOETHANE NIHON NOHYAKU CO., LTD. (JP) 1982-04-27 US disclosed
US-4118506-A LIVER DISORDERS NIHON NOHYAKU CO., LTD. (JP) 1978-10-03 US disclosed
JP-S5283751-A 1,3-DITHIOL-2-YLIDENE MALONIC ACID DERIVATIVE NIPPON NOHYAKU CO LTD 1977-07-12 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10604601-B2 Multifunctional monomers, methods for making multifunctional monomers, polymerizable compositions and products formed therefrom BHMT2, MACF1, BHMT ADRA1A 3208/4885PDE4D 4672/4885
US-10611861-B2 Multifunctional monomers, methods for making multifunctional monomers, polymerizable compositions and products formed thereform MACF1, BHMT2, MTHFD2 ADRA1A 3770/4885PDE4D 4651/4885
US-20180346615-A1 MULTIFUNCTIONAL MONOMERS, METHODS FOR MAKING MULTIFUNCTIONAL MONOMERS, POLYMERIZABLE COMPOSITIONS AND PRODUCTS FORMED THEREFORM MACF1, BHMT2, MTHFD2 ADRA1A 3770/4885PDE4D 4651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.