Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 5/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.45 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27263186 | 0.88 | ALDH1A1 (0.47) | BRD4BRD9PKMALDH1A1NPC1 | |
| SCHEMBL9527005 | 0.88 | ADRA1A (0.52) | BRD4BRD9HTR1AADRA1DADRA1A | |
| SCHEMBL27263520 | 0.86 | KAT2B (0.57) | BRD4BRD9PKMALDH1A1NPC1 | |
| SCHEMBL27263994 | 0.86 | HTR1A (0.57) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL27263977 | 0.85 | BRD4 (0.41) | BRD4BRD9ALDH1A1HTR1AADRA1D | |
| SCHEMBL27264116 | 0.84 | HTR1A (0.48) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL27264164 | 0.84 | BPTF (0.52) | BRD4PKMALDH1A1NPC1KAT2B | |
| SCHEMBL27263628 | 0.84 | ADRA1A (0.47) | BRD4BRD9ALDH1A1HTR1AADRA1D | |
| SCHEMBL27263416 | 0.82 | HTR1A (0.47) | BRD4BRD9HTR1AADRA1DADRA1A | |
| SCHEMBL9528374 | 0.82 | DRD2 (0.58) | BRD4BRD9HTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1022565-C | Process for preparing piperazinylalkyl-3(2H)-pyridazinones | CL PHARMA (AT) | 1993-10-27 | — | — | CN | disclosed |
| CN-1043129-A | New piperazinyl alkyl-3 (2H)-pyridazinone, its preparation method and as the application of hypotensive agent | CL PHARMA (AT) | 1990-06-20 | — | — | CN | disclosed |