Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.52 |
| ▸ | BRD4 | O60885 | 8/20 | 0.51 |
| ▸ | KAT2B | Q92831 | 6/20 | 0.51 |
| ▸ | BRD9 | Q9H8M2 | 6/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.46 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.46 |
| ▸ | BPTF | Q12830 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9528374 | 0.94 | DRD2 (0.58) | ADRA1AHTR1AADRA1DADRA1BBRD4 | |
| SCHEMBL9527047 | 0.88 | BRD4 (0.57) | ADRA1AHTR1AADRA1DADRA1BBRD4 | |
| SCHEMBL27263418 | 0.88 | BRD4 (0.46) | ADRA1AHTR1AADRA1DADRA1BBRD4 | |
| SCHEMBL9531491 | 0.88 | BRD4 (0.51) | ADRA1AHTR1AADRA1DADRA1BBRD4 | |
| SCHEMBL9527346 | 0.86 | ADRA1A (0.65) | ADRA1AHTR1AADRA1DADRA1BDRD2 | |
| SCHEMBL9528184 | 0.85 | ADRA1A (0.58) | ADRA1AHTR1AADRA1DADRA1BBRD4 | |
| SCHEMBL9531572 | 0.85 | KAT2B (0.58) | ADRA1AADRA1DADRA1BBRD4KAT2B | |
| SCHEMBL9526946 | 0.84 | HTR1A (0.53) | ADRA1AHTR1AADRA1DADRA1BBRD4 | |
| SCHEMBL9527377 | 0.84 | ADRA1A (0.54) | ADRA1AHTR1AADRA1DADRA1BBRD4 | |
| SCHEMBL9528853 | 0.83 | KAT2B (0.60) | BRD4KAT2BBRD9DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |