Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 8/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27263519 | 0.85 | TIPARP (0.53) | TSHRDRD4DRD2ALDH1A1MAPT | |
| SCHEMBL27263196 | 0.84 | DRD4 (0.48) | TSHRDRD4DRD2HTR1AALDH1A1 | |
| SCHEMBL27263632 | 0.84 | HTR1A (0.48) | TSHRDRD4DRD2HTR1AALDH1A1 | |
| SCHEMBL27263082 | 0.81 | DRD4 (0.45) | TSHRDRD4DRD2ALDH1A1ALOX15 | |
| SCHEMBL27263291 | 0.80 | DRD2 (0.54) | DRD4DRD2HTR1AADRA1AADRA1B | |
| SCHEMBL27263412 | 0.78 | ADRA1D (0.52) | TSHRDRD4DRD2HTR1AALDH1A1 | |
| SCHEMBL27263185 | 0.77 | TRPC5 (0.51) | TSHRDRD4DRD2HTR1AALDH1A1 | |
| SCHEMBL27263187 | 0.77 | DRD4 (0.48) | TSHRDRD4DRD2HTR1AADRA1D | |
| SCHEMBL27264122 | 0.76 | DRD4 (0.50) | DRD4DRD2HTR1AALDH1A1ALOX15 | |
| SCHEMBL9527044 | 0.75 | HTR1A (0.63) | DRD4DRD2HTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1022565-C | Process for preparing piperazinylalkyl-3(2H)-pyridazinones | CL PHARMA (AT) | 1993-10-27 | — | — | CN | disclosed |
| CN-1043129-A | New piperazinyl alkyl-3 (2H)-pyridazinone, its preparation method and as the application of hypotensive agent | CL PHARMA (AT) | 1990-06-20 | — | — | CN | disclosed |