Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 6/20 | 0.50 |
| ▸ | DRD4 | P21917 | 4/20 | 0.50 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586501 | 0.84 | HTR7 (0.48) | DRD2KCNH2HTR1AHTR2AHTR7 | |
| SCHEMBL27263871 | 0.80 | TSHR (0.48) | DRD2HTR1ADRD4ADRA1AADRA1B | |
| SCHEMBL9527044 | 0.80 | HTR1A (0.63) | DRD2HTR1ADRD4DRD3ADRA1A | |
| SCHEMBL10431149 | 0.79 | HTR7 (0.43) | DRD2HTR1ADRD3HTR7ADRA1A | |
| SCHEMBL27263980 | 0.79 | DRD2 (0.54) | DRD2KCNH2HTR1ADRD4HTR2A | |
| SCHEMBL9531536 | 0.77 | KCNH2 (0.53) | DRD2KCNH2HTR1ADRD4HTR2A | |
| SCHEMBL9528402 | 0.76 | HTR1A (0.61) | DRD2HTR1AHTR2ADRD3HTR7 | |
| SCHEMBL27352770 | 0.76 | DRD3 (0.61) | DRD2KCNH2HTR1ADRD4HTR2A | |
| SCHEMBL9527740 | 0.76 | DRD2 (0.64) | DRD2HTR1ADRD4HTR2ADRD3 | |
| SCHEMBL11446702 | 0.75 | HTR1A (0.67) | DRD2KCNH2HTR1ADRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1022565-C | Process for preparing piperazinylalkyl-3(2H)-pyridazinones | CL PHARMA (AT) | 1993-10-27 | — | — | CN | disclosed |
| CN-1043129-A | New piperazinyl alkyl-3 (2H)-pyridazinone, its preparation method and as the application of hypotensive agent | CL PHARMA (AT) | 1990-06-20 | — | — | CN | disclosed |