Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969493 | 0.82 | ALDH1A1 (0.35) | HSD11B1ALDH1A1HPGDNPC1KMT2A | |
| SCHEMBL14855363 | 0.81 | HSD11B1 (0.48) | HSD11B1POLBALDH1A1HPGDRAB9A | |
| SCHEMBL6963781 | 0.80 | HSD11B1 (0.31) | HSD11B1ALDH1A1HPGDCTSLCTSS | |
| SCHEMBL2861230 | 0.77 | ENPP2 (0.42) | ALDH1A1HPGDKDM4ETSHR | |
| SCHEMBL9550362 | 0.76 | CES2 (0.42) | HSD11B1POLBALDH1A1HPGDCTSL | |
| SCHEMBL9463888 | 0.76 | NSD2 (0.36) | POLBALDH1A1HPGDNPC1KMT2A | |
| SCHEMBL28250962 | 0.75 | POLB (0.43) | HSD11B1POLBALDH1A1HPGDCTSL | |
| SCHEMBL4039494 | 0.75 | ALDH1A1 (0.58) | HSD11B1ALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL30062 | 0.75 | ALDH1A1 (0.58) | HSD11B1ALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL2220361 | 0.75 | ALDH1A1 (0.55) | HSD11B1POLBALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632915-A1 | BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION | Boehringer Ingelheim International GmbH (DE) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058254-A1 | BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-03 | — | — | WO | disclosed |
| US-6967196-B1 | Sulfonamide compounds and uses thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| EP-0087393-B1 | PROCESS FOR THE PREPARATION OF ISOMELAMINES, AND THEIR USE | CIBA-GEIGY AG (CH) | 1987-01-14 | — | — | EP | disclosed |
| EP-0087394-B1 | PROCESS FOR THE PREPARATION OF N-SUBSTITUTED N-CYANO-AMIDES AND THEIR USE | CIBA-GEIGY AG (CH) | 1986-05-14 | — | — | EP | disclosed |
| US-4550203-A | REACTING AMIDE SALT WITH ALKYLATING AGENT | CIBA GEIGY CORPORATION (US) | 1985-10-29 | — | — | US | disclosed |
| US-4537946-A | POLYEDOXIDE CURING AGENTS | CIBA-GEIGY CORPORATION (US) | 1985-08-27 | — | — | US | disclosed |
| US-4499268-A | REACTING N-CYANO-N-(AR OR CYCLO)ALKYLCARBOXLIC AMINE WITH EITHER SODIUM(OR POTASSIUM) HYDROXIDE), AMINE, OR ALCOHOL | CIBA GEIGY CORPORATION (US) | 1985-02-12 | — | — | US | disclosed |
| EP-0087393-A2 | Process for the preparation of isomelamines, and their use | CIBA-GEIGY AG (CH) | 1983-08-31 | — | — | EP | disclosed |
| EP-0087394-A2 | Process for the preparation of N-substituted N-cyano-amides and their use | CIBA-GEIGY AG (CH) | 1983-08-31 | — | — | EP | disclosed |