Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | YWHAG | P61981 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10139201 | 0.84 | CYP1A2 (0.52) | ACKR3MAPTKDM4EHSD17B10CYP1A2 | |
| SCHEMBL3758177 | 0.81 | CYP1A2 (0.47) | ACKR3MAPTMEN1ALOX15KMT2A | |
| SCHEMBL13054790 | 0.81 | ACKR3 (0.39) | ACKR3MAPTGFERCYP1A2CYP3A4 | |
| SCHEMBL27835961 | 0.81 | ALKBH2 (0.45) | BTKMAP4K4MAPTHPGDSALKBH2 | |
| SCHEMBL14320344 | 0.76 | TDO2 (0.49) | MAPTGFERKDM4EMEN1THRB | |
| SCHEMBL10139147 | 0.75 | MAP4K4 (0.56) | BTKMAP4K4MAPTKDM4EMEN1 | |
| SCHEMBL4647029 | 0.74 | ALKBH1 (0.56) | ACKR3HPGDSALKBH2EGLN1NPC1 | |
| SCHEMBL30132085 | 0.74 | HPGDS (0.51) | BTKMAP4K4MAPTMEN1KMT2A | |
| SCHEMBL4481678 | 0.74 | HPGDS (0.51) | BTKMAP4K4MAPTMEN1KMT2A | |
| SCHEMBL30529091 | 0.74 | ALKBH1 (0.56) | ACKR3HPGDSALKBH2EGLN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012059932-A1 | 2, 4 -DIAMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012059932-A1 | 2, 4 -DIAMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-10 | — | — | WO | disclosed |