Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ICMT | O60725 | 11/20 | 0.40 |
| ▸ | HEXA | P06865 | 1/20 | 0.40 |
| ▸ | HEXB | P07686 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729484 | 0.87 | BCHE (0.38) | BCHEACHEHASPIN | |
| SCHEMBL2729483 | 0.87 | BCHE (0.38) | BCHEACHEHASPIN | |
| SCHEMBL2719938 | 0.83 | LIMK1 (0.52) | ICMT | |
| SCHEMBL14425470 | 0.77 | ICMT (0.47) | BCHEACHEICMTMAP4K4SIRT2 | |
| SCHEMBL15312161 | 0.77 | BCHE (0.44) | BCHEACHEHASPIN | |
| SCHEMBL2720296 | 0.76 | ALKBH5 (0.49) | BCHEACHEHASPIN | |
| SCHEMBL28928549 | 0.74 | ACHE (0.60) | BCHEACHEHASPIN | |
| SCHEMBL25785204 | 0.71 | GPR3 (0.53) | BCHEACHEICMT | |
| SCHEMBL13564062 | 0.70 | MAOB (0.47) | ICMTMAPK14MAP4K4SIRT2 | |
| SCHEMBL23622439 | 0.68 | RXFP1 (0.47) | BCHEACHEICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635575-A1 | CARBAZOLE AND CARBOLINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC APPLICATIONS THEREOF | Philip Morris Products S.a.s. (CH) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012059232-A1 | CARBAZOLE AND CARBOLINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC APPLICATIONS THEREOF | PHILIP MORRIS PRODUCTS S.A (CH) | 2012-05-10 | — | — | WO | disclosed |