Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27319189 | 0.85 | GFER (0.49) | PTGS2LMNAGFERRECQLKMT2A | |
| SCHEMBL27311725 | 0.81 | ALDH1A1 (0.48) | LMNAGFERKMT2ATP53GAA | |
| SCHEMBL28148161 | 0.81 | NPC1 (0.56) | PTGS2LMNAGFERMAPK1SMN1; SMN2 | |
| SCHEMBL27408901 | 0.81 | KMT2A (0.49) | GFERKMT2ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL27315064 | 0.81 | ALDH1A1 (0.50) | LMNAGFERKMT2ATP53ALDH1A1 | |
| SCHEMBL27325273 | 0.81 | KMT2A (0.54) | PTGS2LMNAGFERKMT2AMAPK1 | |
| SCHEMBL27315061 | 0.79 | CYP1A2 (0.49) | GFERKMT2ASMN1; SMN2 | |
| SCHEMBL27309740 | 0.79 | KMT2A (0.50) | PTGS2GFERKMT2ATP53ALDH1A1 | |
| SCHEMBL27315971 | 0.78 | TP53 (0.46) | LMNAGFERRECQLKMT2ASMN1; SMN2 | |
| SCHEMBL27318291 | 0.77 | PKM (0.52) | LMNAGFERRECQLKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1051074-C | Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides pharmaceuticals containing these compounds and their use | HOECHST AG (DE) | 2000-04-05 | — | — | CN | disclosed |