Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27319189 | 0.81 | GFER (0.49) | TP53GAASMN1; SMN2RECQLKMT2A | |
| SCHEMBL27322188 | 0.78 | PTGS2 (0.59) | TP53GAASMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL27408901 | 0.75 | KMT2A (0.49) | TP53NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL28148161 | 0.75 | NPC1 (0.56) | TP53NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL27325273 | 0.75 | KMT2A (0.54) | TP53GAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27315064 | 0.75 | ALDH1A1 (0.50) | TP53ALDH1A1HSD17B10KDM4EPOLB | |
| SCHEMBL27311725 | 0.75 | ALDH1A1 (0.48) | TP53GAAALDH1A1KDM4EMAPT | |
| SCHEMBL27323098 | 0.74 | HIF1A (0.53) | TP53GAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27309740 | 0.73 | KMT2A (0.50) | TP53NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL27315061 | 0.73 | CYP1A2 (0.49) | NPC1RAB9ASMN1; SMN2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1051074-C | Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides pharmaceuticals containing these compounds and their use | HOECHST AG (DE) | 2000-04-05 | — | — | CN | disclosed |